Deep vein thrombosis and systemic inflammatory response: a pilot trial

Symptoms of deep vein thrombosis as swelling, erythema, pain and calor have been suspected of being caused by an inflammatory reaction of the affected leg. We therefore performed a prospective pilot trial to study a possible systemic inflammatory response induced by deep vein thrombosis. We determin...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2003-02, Vol.115 (3-4), p.111-114
Main Authors: Reiter, Markus, Bucek, Robert A, Koca, Nihat, Dirisamer, Albert, Minar, Erich
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - blood
Acute-Phase Reaction - physiopathology
Adult
Aged
C-Reactive Protein - analysis
Data Interpretation, Statistical
Female
Humans
Inflammation - blood
Inflammation - physiopathology
Leukocyte Count
Male
Middle Aged
Multivariate Analysis
Phlebography
Pilot Projects
Prospective Studies
Thrombophlebitis - diagnostic imaging
Thrombophlebitis - physiopathology
Ultrasonography, Doppler, Duplex
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Summary:Symptoms of deep vein thrombosis as swelling, erythema, pain and calor have been suspected of being caused by an inflammatory reaction of the affected leg. We therefore performed a prospective pilot trial to study a possible systemic inflammatory response induced by deep vein thrombosis. We determined white blood cell count and plasma C-reactive protein in 100 consecutive patients with suspected deep vein thrombosis. The final diagnosis was based on the results of duplex sonography or ascending venography. Deep vein thrombosis was diagnosed in 37 patients (37%). White blood cell count (P = 0.012) and plasma C-reactive protein values (P < 0.001) were significantly increased in patients suffering from deep vein thrombosis. There was no correlation of white blood cell count or C-reactive protein with the thrombotic burden or the duration of symptoms. In patients with deep vein thrombosis, thrombus formation and consequent vein wall damage induce a systemic inflammatory reaction which is reflected by significantly increased levels of white blood cells and plasma C-reactive protein.
ISSN:0043-5325
1613-7671
DOI:10.1007/BF03040289