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Requirements for growing tissue-engineered vascular grafts
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| Published in: | Cardiovascular pathology 2003-03, Vol.12 (2), p.59-64 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c427t-5febae4592142b943122d6104790b9aa5bdee28ce350c0f97816a38acacfc72a3 |
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| cites | cdi_FETCH-LOGICAL-c427t-5febae4592142b943122d6104790b9aa5bdee28ce350c0f97816a38acacfc72a3 |
| container_end_page | 64 |
| container_issue | 2 |
| container_start_page | 59 |
| container_title | Cardiovascular pathology |
| container_volume | 12 |
| creator | Mitchell, Shannon L. Niklason, Laura E. |
| description | Small diameter ( |
| doi_str_mv | 10.1016/S1054-8807(02)00183-7 |
| format | article |
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Although synthetic grafts have been developed, tissue-based vascular grafts that can better mimic native vessels will likely yield superior results. The success of a tissue-based graft depends on its ability to meet several requirements. First, a graft must possess a confluent, adherent and quiescent endothelium to resist thrombosis in vivo. The mechanical behavior of the graft must mimic the mechanical properties of a native vessel. Hence, a graft must have a highly organized collagen matrix to impart tissue strength. 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Although synthetic grafts have been developed, tissue-based vascular grafts that can better mimic native vessels will likely yield superior results. The success of a tissue-based graft depends on its ability to meet several requirements. First, a graft must possess a confluent, adherent and quiescent endothelium to resist thrombosis in vivo. The mechanical behavior of the graft must mimic the mechanical properties of a native vessel. Hence, a graft must have a highly organized collagen matrix to impart tissue strength. 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| fulltext | fulltext |
| identifier | ISSN: 1054-8807 |
| ispartof | Cardiovascular pathology, 2003-03, Vol.12 (2), p.59-64 |
| issn | 1054-8807 1879-1336 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73175493 |
| source | ScienceDirect Journals |
| subjects | Biocompatible Materials Blood Vessel Prosthesis Humans Tissue Engineering - methods Transplants |
| title | Requirements for growing tissue-engineered vascular grafts |
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