Evidence that Hensen's node is a site of retinoic acid synthesis

HENSEN'S node of amniotes, like the Spemann organizer of amphibians, can induce a second body axis when grafted into a host embryo 1 . The avian node, as well as several midline structures originating from it (notochord, floor plate), can also induce digit pattern duplications when grafted into...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1992-09, Vol.359 (6392), p.237-241
Main Authors: Hogan, Brigid L. M., Thaller, Christina, Eichele, Gregor
Format: Article
Language:English
Subjects:
Amphibians
Animals
Biological and medical sciences
Chick Embryo
Chromatography, High Pressure Liquid
Embryology: invertebrates and vertebrates. Teratology
Embryos
Forelimb - embryology
Fundamental and applied biological sciences. Psychology
Humanities and Social Sciences
Humans
letter
Medical research
Mice - embryology
Mice, Inbred ICR
Models, Biological
multidisciplinary
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Rodents
Science
Science (multidisciplinary)
Transplantation, Heterologous
Tretinoin - metabolism
Vitamin A - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73
cites cdi_FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73
container_end_page 241
container_issue 6392
container_start_page 237
container_title Nature (London)
container_volume 359
creator Hogan, Brigid L. M.
Thaller, Christina
Eichele, Gregor
description HENSEN'S node of amniotes, like the Spemann organizer of amphibians, can induce a second body axis when grafted into a host embryo 1 . The avian node, as well as several midline structures originating from it (notochord, floor plate), can also induce digit pattern duplications when grafted into the chick wing bud 2,3 . We report here that the equivalent of Hensen's node from mouse is an effective inducer of digits in the chick wing bud. Tissues anterior and posterior to the node also evoke pattern duplications, but with a significantly lower efficiency. The finding that the murine node operates in an avian wing bud suggests that the same inducing agent(s) function in both primary and secondary embryonic fields and have been conserved during vertebrate evolution. Digit pattern duplications are also evoked by local administration of all- trans -retinoic acid 4,5 . This similarity raises the possibility that Hensen's node is a source of retinoic acid. The mouse node is capable of synthesizing retinoic acid from its biosynthetic precursor all- trans -retinol at a substantially higher rate than either anterior or posterior tissues.
doi_str_mv 10.1038/359237a0
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73176238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4945568</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73</originalsourceid><addsrcrecordid>eNplkMtKBDEURIMoOj7AHxCCiI9Fa27SSTo7ZfAFghtdN5n0bY3MpDW3R_DvbZlRQVe1qENVUYztgjgFoaozpZ1U1osVNoLSmqI0lV1lIyFkVYhKmQ22SfQihNBgy3W2DlpW0ugRO798jw2mgLx_9j2_wUSYjoinrkEeiXtOsUfetTxjH1MXA_chNpw-Uv-MFGmbrbV-Sriz1C32eHX5ML4p7u6vb8cXd0WQlRKFbJ3RpQ0eWomlNmCMEJN22OoDOnBQOvATFNI5MKCV9hYcTqwOlQTTWLXFDhe5r7l7myP19SxSwOnUJ-zmVFsF1khVDeD-H_Clm-c0bKulKEulpVMDdLyAQu6IMrb1a44znz9qEPXXo_X3owO6t8ybT2bY_IKLCwf_YOl7Cn7aZp9CpB9Ma2kFfDWeLDAanPSE-XfWv8pPpHSGYw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204435293</pqid></control><display><type>article</type><title>Evidence that Hensen's node is a site of retinoic acid synthesis</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>Hogan, Brigid L. M. ; Thaller, Christina ; Eichele, Gregor</creator><creatorcontrib>Hogan, Brigid L. M. ; Thaller, Christina ; Eichele, Gregor</creatorcontrib><description>HENSEN'S node of amniotes, like the Spemann organizer of amphibians, can induce a second body axis when grafted into a host embryo 1 . The avian node, as well as several midline structures originating from it (notochord, floor plate), can also induce digit pattern duplications when grafted into the chick wing bud 2,3 . We report here that the equivalent of Hensen's node from mouse is an effective inducer of digits in the chick wing bud. Tissues anterior and posterior to the node also evoke pattern duplications, but with a significantly lower efficiency. The finding that the murine node operates in an avian wing bud suggests that the same inducing agent(s) function in both primary and secondary embryonic fields and have been conserved during vertebrate evolution. Digit pattern duplications are also evoked by local administration of all- trans -retinoic acid 4,5 . This similarity raises the possibility that Hensen's node is a source of retinoic acid. The mouse node is capable of synthesizing retinoic acid from its biosynthetic precursor all- trans -retinol at a substantially higher rate than either anterior or posterior tissues.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/359237a0</identifier><identifier>PMID: 1528265</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amphibians ; Animals ; Biological and medical sciences ; Chick Embryo ; Chromatography, High Pressure Liquid ; Embryology: invertebrates and vertebrates. Teratology ; Embryos ; Forelimb - embryology ; Fundamental and applied biological sciences. Psychology ; Humanities and Social Sciences ; Humans ; letter ; Medical research ; Mice - embryology ; Mice, Inbred ICR ; Models, Biological ; multidisciplinary ; Organogenesis. Fetal development ; Organogenesis. Physiological fonctions ; Rodents ; Science ; Science (multidisciplinary) ; Transplantation, Heterologous ; Tretinoin - metabolism ; Vitamin A - metabolism</subject><ispartof>Nature (London), 1992-09, Vol.359 (6392), p.237-241</ispartof><rights>Springer Nature Limited 1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Sep 17, 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73</citedby><cites>FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=5527013$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1528265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hogan, Brigid L. M.</creatorcontrib><creatorcontrib>Thaller, Christina</creatorcontrib><creatorcontrib>Eichele, Gregor</creatorcontrib><title>Evidence that Hensen's node is a site of retinoic acid synthesis</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>HENSEN'S node of amniotes, like the Spemann organizer of amphibians, can induce a second body axis when grafted into a host embryo 1 . The avian node, as well as several midline structures originating from it (notochord, floor plate), can also induce digit pattern duplications when grafted into the chick wing bud 2,3 . We report here that the equivalent of Hensen's node from mouse is an effective inducer of digits in the chick wing bud. Tissues anterior and posterior to the node also evoke pattern duplications, but with a significantly lower efficiency. The finding that the murine node operates in an avian wing bud suggests that the same inducing agent(s) function in both primary and secondary embryonic fields and have been conserved during vertebrate evolution. Digit pattern duplications are also evoked by local administration of all- trans -retinoic acid 4,5 . This similarity raises the possibility that Hensen's node is a source of retinoic acid. The mouse node is capable of synthesizing retinoic acid from its biosynthetic precursor all- trans -retinol at a substantially higher rate than either anterior or posterior tissues.</description><subject>Amphibians</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chick Embryo</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryos</subject><subject>Forelimb - embryology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Medical research</subject><subject>Mice - embryology</subject><subject>Mice, Inbred ICR</subject><subject>Models, Biological</subject><subject>multidisciplinary</subject><subject>Organogenesis. Fetal development</subject><subject>Organogenesis. Physiological fonctions</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Transplantation, Heterologous</subject><subject>Tretinoin - metabolism</subject><subject>Vitamin A - metabolism</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNplkMtKBDEURIMoOj7AHxCCiI9Fa27SSTo7ZfAFghtdN5n0bY3MpDW3R_DvbZlRQVe1qENVUYztgjgFoaozpZ1U1osVNoLSmqI0lV1lIyFkVYhKmQ22SfQihNBgy3W2DlpW0ugRO798jw2mgLx_9j2_wUSYjoinrkEeiXtOsUfetTxjH1MXA_chNpw-Uv-MFGmbrbV-Sriz1C32eHX5ML4p7u6vb8cXd0WQlRKFbJ3RpQ0eWomlNmCMEJN22OoDOnBQOvATFNI5MKCV9hYcTqwOlQTTWLXFDhe5r7l7myP19SxSwOnUJ-zmVFsF1khVDeD-H_Clm-c0bKulKEulpVMDdLyAQu6IMrb1a44znz9qEPXXo_X3owO6t8ybT2bY_IKLCwf_YOl7Cn7aZp9CpB9Ma2kFfDWeLDAanPSE-XfWv8pPpHSGYw</recordid><startdate>19920917</startdate><enddate>19920917</enddate><creator>Hogan, Brigid L. M.</creator><creator>Thaller, Christina</creator><creator>Eichele, Gregor</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>19920917</creationdate><title>Evidence that Hensen's node is a site of retinoic acid synthesis</title><author>Hogan, Brigid L. M. ; Thaller, Christina ; Eichele, Gregor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amphibians</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chick Embryo</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryos</topic><topic>Forelimb - embryology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Medical research</topic><topic>Mice - embryology</topic><topic>Mice, Inbred ICR</topic><topic>Models, Biological</topic><topic>multidisciplinary</topic><topic>Organogenesis. Fetal development</topic><topic>Organogenesis. Physiological fonctions</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Transplantation, Heterologous</topic><topic>Tretinoin - metabolism</topic><topic>Vitamin A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hogan, Brigid L. M.</creatorcontrib><creatorcontrib>Thaller, Christina</creatorcontrib><creatorcontrib>Eichele, Gregor</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest research library</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hogan, Brigid L. M.</au><au>Thaller, Christina</au><au>Eichele, Gregor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that Hensen's node is a site of retinoic acid synthesis</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1992-09-17</date><risdate>1992</risdate><volume>359</volume><issue>6392</issue><spage>237</spage><epage>241</epage><pages>237-241</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>HENSEN'S node of amniotes, like the Spemann organizer of amphibians, can induce a second body axis when grafted into a host embryo 1 . The avian node, as well as several midline structures originating from it (notochord, floor plate), can also induce digit pattern duplications when grafted into the chick wing bud 2,3 . We report here that the equivalent of Hensen's node from mouse is an effective inducer of digits in the chick wing bud. Tissues anterior and posterior to the node also evoke pattern duplications, but with a significantly lower efficiency. The finding that the murine node operates in an avian wing bud suggests that the same inducing agent(s) function in both primary and secondary embryonic fields and have been conserved during vertebrate evolution. Digit pattern duplications are also evoked by local administration of all- trans -retinoic acid 4,5 . This similarity raises the possibility that Hensen's node is a source of retinoic acid. The mouse node is capable of synthesizing retinoic acid from its biosynthetic precursor all- trans -retinol at a substantially higher rate than either anterior or posterior tissues.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1528265</pmid><doi>10.1038/359237a0</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0028-0836
ispartof Nature (London), 1992-09, Vol.359 (6392), p.237-241
issn 0028-0836
1476-4687
language eng
recordid cdi_proquest_miscellaneous_73176238
source Springer Nature - Connect here FIRST to enable access
subjects Amphibians
Animals
Biological and medical sciences
Chick Embryo
Chromatography, High Pressure Liquid
Embryology: invertebrates and vertebrates. Teratology
Embryos
Forelimb - embryology
Fundamental and applied biological sciences. Psychology
Humanities and Social Sciences
Humans
letter
Medical research
Mice - embryology
Mice, Inbred ICR
Models, Biological
multidisciplinary
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Rodents
Science
Science (multidisciplinary)
Transplantation, Heterologous
Tretinoin - metabolism
Vitamin A - metabolism
title Evidence that Hensen's node is a site of retinoic acid synthesis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T12%3A29%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20that%20Hensen's%20node%20is%20a%20site%20of%20retinoic%20acid%20synthesis&rft.jtitle=Nature%20(London)&rft.au=Hogan,%20Brigid%20L.%20M.&rft.date=1992-09-17&rft.volume=359&rft.issue=6392&rft.spage=237&rft.epage=241&rft.pages=237-241&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/359237a0&rft_dat=%3Cproquest_cross%3E4945568%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2830-2f96547ca1f2e45616600bf476ace9191491abe0299161535a719eb75c8216d73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=204435293&rft_id=info:pmid/1528265&rfr_iscdi=true