Hepatitis viruses and the MAPK pathway: is this a survival strategy?

The viruses that cause hepatitis comprise of at least five different agents, which share the ability to cause inflammation and necrosis of the liver. The disease spectrum is quite diverse and the outcome of infection by the different hepatitis viruses can be rationalized based on virus-host cell int...

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Bibliographic Details
Published in:Virus Research 2003-04, Vol.92 (2), p.131-140
Main Authors: Panteva, Milena, Korkaya, Hasan, Jameel, Shahid
Format: Article
Language:English
Subjects:
Animals
Hepacivirus - pathogenicity
Hepatitis B virus - pathogenicity
Hepatitis E virus - pathogenicity
Hepatitis virus
Hepatitis, Viral, Animal - physiopathology
Hepatitis, Viral, Animal - virology
Hepatitis, Viral, Human - physiopathology
Hepatitis, Viral, Human - virology
Hepatocellular carcinoma
Humans
Mice
Mitogen-Activated Protein Kinases - metabolism
Viral hepatitis
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Summary:The viruses that cause hepatitis comprise of at least five different agents, which share the ability to cause inflammation and necrosis of the liver. The disease spectrum is quite diverse and the outcome of infection by the different hepatitis viruses can be rationalized based on virus-host cell interactions. New insights into the molecular basis of viral hepatitis reveal that three of these agents – the hepatitis B, C and E viruses (HBV, HCV and HEV) modulate the mitogen-activated protein kinase (MAPK) signaling pathway. In this review we briefly describe the structural organization of the MAPK cascade and emphasize its importance as a central pathway in the signaling network. Selected mechanisms through which HBV, HCV and HEV proteins target various steps in the MAPK pathway are discussed and used to propose a pro-survival outcome for the host cell. In addition, we offer an insight into how the common theme of MAPK activation and its downstream effects may be used to rationalize the different outcomes of hepatitis B, C and E.
ISSN:0168-1702
1872-7492
DOI:10.1016/S0168-1702(02)00356-8