Identification of a novel HLA-DRB1 allele: DRB11353

: In this report we describe a new HLA‐DRB1 allele, DRB1*1353, which was initially recognized by a discrepancy between the results obtained with polymerase chain reaction using sequence‐specific oligonucleotide (PCR‐SSO) and sequence‐specific primers (PCR‐SSP). Sequence‐based typing revealed sequenc...

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Bibliographic Details
Published in:Tissue antigens 2003-02, Vol.61 (2), p.177-178
Main Authors: Longhi, E., Frison, S., Poli, F., Gaboardi, D., Ferrioli, G., Scalamogna, M.
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Substitution
Base Sequence
DNA - genetics
Female
HLA-DR Antigens - genetics
HLA-DRB1
HLA-DRB1 Chains
Humans
Polymerase Chain Reaction
SBT
Sequence Homology, Nucleic Acid
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Summary:: In this report we describe a new HLA‐DRB1 allele, DRB1*1353, which was initially recognized by a discrepancy between the results obtained with polymerase chain reaction using sequence‐specific oligonucleotide (PCR‐SSO) and sequence‐specific primers (PCR‐SSP). Sequence‐based typing revealed sequence differences with other known HLA‐DRB1 alleles. DRB1*1353 is identical to DRB1*13011 except for two nucleotide substitutions at nucleotide 84 (C(r)G) and at nucleotide 140 (T(r)A). These differences give rise to two amino acid substitutions at codons 28 and 47 from Asp to Glu and from Phe to Tyr, respectively.
ISSN:0001-2815
1399-0039
DOI:10.1046/j.0001-2815.2002.00006.x