A comparison of CA-549 with CA 15-3 and MCA in patients with metastatic breast cancer

CA 15-3, MCA, and CA-549 levels were determined in the serum of 56 patients with metastatic breast cancer, all of whom had visceral and/or bone metastases. CA 15-3 was positive in the serum of 37 patients, MCA in the serum of 38 patients, and CA-549 in the serum of 39 patients. All 3 markers were po...

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Bibliographic Details
Published in:Annals of oncology 1992-04, Vol.3 (4), p.314-315
Main Authors: de Wit, R., Hoek, F. J., Bakker, P. J. M., Veenhof, C. H. N.
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - analysis
Antigens, Tumor-Associated, Carbohydrate - analysis
Biological and medical sciences
Biomarkers, Tumor - analysis
breast cancer
Breast Neoplasms - immunology
CA 15-3
CA-549
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
MCA
Medical sciences
Neoplasm Metastasis
Tumors
tumour markers
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Summary:CA 15-3, MCA, and CA-549 levels were determined in the serum of 56 patients with metastatic breast cancer, all of whom had visceral and/or bone metastases. CA 15-3 was positive in the serum of 37 patients, MCA in the serum of 38 patients, and CA-549 in the serum of 39 patients. All 3 markers were positive in 36 patients, and all 3 were negative in 16 patients. In the serum of 4 patients only 1 or 2 markers were slightly elevated. Thus, the results were identical in 52 of the 56 patients. It is concluded that CA 15-3, MCA, and CA-549 are sensitive markers for advanced breast cancer, and that no advantage can be expected by combining them.
ISSN:0923-7534
1569-8041
DOI:10.1093/oxfordjournals.annonc.a058190