Cerebral MR Spectroscopy In Neurologically Asymptomatic Hiv‐Infected Patients

Purpose:  To detect early metabolic changes in the brain of neurologically asymptomatic HIV‐infected patients with normal MR imaging and to find the correlation between 1H MR results and immune status. Material and Methods:  Twenty neurologically asymptomatic HIV seropositive patients underwent MR i...

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Bibliographic Details
Published in:Acta radiologica (1987) 2003-03, Vol.44 (2), p.206-212
Main Authors: Tarasów, E., Wiercińska‐Drapało, A., Kubas, B., Dzienis, W., Orzechowska‐Bobkiewicz, A., Prokopowicz, D., Walecki, J.
Format: Article
Language:English
Subjects:
Acquired immunodeficiency syndrome (AIDS)
Adult
Biological and medical sciences
Brain - metabolism
Female
HIV Infections - metabolism
Human immunodeficiency virus
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
MR spectroscopy
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Purpose:  To detect early metabolic changes in the brain of neurologically asymptomatic HIV‐infected patients with normal MR imaging and to find the correlation between 1H MR results and immune status. Material and Methods:  Twenty neurologically asymptomatic HIV seropositive patients underwent MR imaging and single‐voxel 1H MR spectroscopy (MRS) using a PRESS sequence. For all patients, the signals from N‐acetyl‐aspartate (NAA), choline‐containing compounds (Cho), creatine‐phosphocreatine (Cr) and myoinositol (mI) were compared with 32 healthy volunteers as metabolite ratios and metabolite areas to non‐suppressed water area ratios. Results:  In HIV patients, the NAA/Cho ratio was significantly lower ( p 
ISSN:0284-1851
1600-0455
DOI:10.1034/j.1600-0455.2003.00028.x