TB or Not TB: How Mycobacterium tuberculosis May Evade Drug Treatment

In this issue of Cell, a study by Valerie Mizrahi and her colleagues (Boshoff et al., 2003) suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanis...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2003-04, Vol.113 (2), p.139-140
Main Authors: Friedberg, Errol C, Fischhaber, Paula L
Format: Article
Language:English
Subjects:
Animals
DNA Damage - genetics
DNA-Directed DNA Polymerase - genetics
Drug Resistance, Bacterial - genetics
Gene Expression Regulation, Bacterial - genetics
Gene Expression Regulation, Enzymologic - genetics
Humans
Mutation - genetics
Mycobacterium tuberculosis - enzymology
Mycobacterium tuberculosis - genetics
Tuberculosis, Multidrug-Resistant - enzymology
Tuberculosis, Multidrug-Resistant - genetics
Tuberculosis, Multidrug-Resistant - physiopathology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this issue of Cell, a study by Valerie Mizrahi and her colleagues (Boshoff et al., 2003) suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(03)00275-7