Transient cerebral arteriopathy in infancy associated with enteroviral infection

We report the case of an 18-month-old boy who presented aphasia and right hemiplegia of acute onset. The neurological deficit completely resolved after a few hours, but identical transient neurological deficits and seizures occurred during the following days. Imaging showed proximal stenosis of the...

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Bibliographic Details
Published in:European journal of paediatric neurology 2003-01, Vol.7 (2), p.73-75
Main Authors: RibaI, Pascale, Liesnard, Corinne, Rodesch, Georges, Giurgea, Sanda, Verheulpen, Denis, David, Philippe, Van Bogaert, Patrick
Format: Article
Language:English
Subjects:
Arteriopathy
Childhood
Constriction, Pathologic
Enterovirus
Enterovirus Infections - cerebrospinal fluid
Enterovirus Infections - complications
Humans
Infant
Infection
Ischemic Attack, Transient - diagnostic imaging
Ischemic Attack, Transient - virology
Magnetic Resonance Angiography
Male
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - pathology
Polymerase Chain Reaction
Radiography
Remission, Spontaneous
Seizures - cerebrospinal fluid
Seizures - virology
Stroke
Virus
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Summary:We report the case of an 18-month-old boy who presented aphasia and right hemiplegia of acute onset. The neurological deficit completely resolved after a few hours, but identical transient neurological deficits and seizures occurred during the following days. Imaging showed proximal stenosis of the medial cerebral artery and deep ischaemic lesions in the territory of this artery. Analysis of the cerebrospinal fluid showed pleocytosis and an active enteroviral infection with positive RNA detection. The evolution was consistent with transient cerebral arteriopathy of childhood as magnetic resonance angiography showed normalization of the arterial lesions. This is the first report of an enteroviral infection associated with this entity. We want to stress the importance of performing a cerebrospinal fluid analysis when an ischaemic stroke of unclear aetiology occurs in a child.
ISSN:1090-3798
1532-2130
DOI:10.1016/S1090-3798(03)00016-3