High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents

The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1992-06, Vol.81 (6), p.577-580
Main Authors: Alvarez‐Builla, Julio, Crespo, Teresa, Lopez, Raquel, Elguero, Jose, Toiron, Catherine, Yranzo, Gloria I.
Format: Article
Language:English
Subjects:
Azoles - analysis
Azoles - chemistry
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Regression Analysis
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
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Summary:The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600810623