High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents

The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1992-06, Vol.81 (6), p.577-580
Main Authors: Alvarez‐Builla, Julio, Crespo, Teresa, Lopez, Raquel, Elguero, Jose, Toiron, Catherine, Yranzo, Gloria I.
Format: Article
Language:English
Subjects:
Azoles - analysis
Azoles - chemistry
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Regression Analysis
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4963-945190d36ae17ea1e08a7550f0df2b3d6946638b082c7e9ea90cdb14460f746c3
cites
container_end_page 580
container_issue 6
container_start_page 577
container_title Journal of pharmaceutical sciences
container_volume 81
creator Alvarez‐Builla, Julio
Crespo, Teresa
Lopez, Raquel
Elguero, Jose
Toiron, Catherine
Yranzo, Gloria I.
description The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.
doi_str_mv 10.1002/jps.2600810623
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73189820</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S002235491548846X</els_id><sourcerecordid>73189820</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4963-945190d36ae17ea1e08a7550f0df2b3d6946638b082c7e9ea90cdb14460f746c3</originalsourceid><addsrcrecordid>eNqFkc9u1DAQhy0EKkvhyg0pB8Qty9hJnPhYbWFLtZRC-XezHGfSdUnire0Ay6mPwJvxDjwJrrJqxQFxsCx5vt94_JmQxxTmFIA9v9j4OeMAFQXOsjtkRgsGKQda3iWzCLA0K3Jxnzzw_gIAOBTFHtmLEMtFNSPtkTlf_776eYquta5Xg8ZkZS5H0ySLtbO9Cvbcqc3a6OQQA7reDCoYOyS2TcIak19XyUfVjeivDw5-2C72Oolr2yVnY-2DCSMOwT8k91rVeXy02_fJh5cv3i-O0tWb5avFwSrVueBZKvKCCmgyrpCWqChCpcqigBaaltVZw0XOeVbVUDFdokAlQDc1zXMObZlzne2TZ1PfjbOXcaoge-M1dp0a0I5elhmtRMUggvMJ1M5677CVG2d65baSgrwWK6NYeSs2Bp7sOo91j80tPpmM9ae7uvJada2LKo2_wQpW5YKWERMT9s10uP3PpfL49OyvEdIpa3zA7zdZ5b5IXmZlIT-dLOXr47e5WK7eyc-RryYeo_GvBp302mD84cY41EE21vzrtX8ATvu2vg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73189820</pqid></control><display><type>article</type><title>High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents</title><source>Wiley Online Library Journals</source><creator>Alvarez‐Builla, Julio ; Crespo, Teresa ; Lopez, Raquel ; Elguero, Jose ; Toiron, Catherine ; Yranzo, Gloria I.</creator><creatorcontrib>Alvarez‐Builla, Julio ; Crespo, Teresa ; Lopez, Raquel ; Elguero, Jose ; Toiron, Catherine ; Yranzo, Gloria I.</creatorcontrib><description>The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600810623</identifier><identifier>PMID: 1522498</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Azoles - analysis ; Azoles - chemistry ; Biological and medical sciences ; Chemical Phenomena ; Chemistry, Physical ; Chromatography, High Pressure Liquid ; General pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Regression Analysis ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of pharmaceutical sciences, 1992-06, Vol.81 (6), p.577-580</ispartof><rights>1992 Wiley Liss, Inc., A Wiley Company</rights><rights>Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4963-945190d36ae17ea1e08a7550f0df2b3d6946638b082c7e9ea90cdb14460f746c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600810623$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600810623$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=5284917$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1522498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alvarez‐Builla, Julio</creatorcontrib><creatorcontrib>Crespo, Teresa</creatorcontrib><creatorcontrib>Lopez, Raquel</creatorcontrib><creatorcontrib>Elguero, Jose</creatorcontrib><creatorcontrib>Toiron, Catherine</creatorcontrib><creatorcontrib>Yranzo, Gloria I.</creatorcontrib><title>High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.</description><subject>Azoles - analysis</subject><subject>Azoles - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Chromatography, High Pressure Liquid</subject><subject>General pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Regression Analysis</subject><subject>Spectrophotometry, Infrared</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqFkc9u1DAQhy0EKkvhyg0pB8Qty9hJnPhYbWFLtZRC-XezHGfSdUnire0Ay6mPwJvxDjwJrrJqxQFxsCx5vt94_JmQxxTmFIA9v9j4OeMAFQXOsjtkRgsGKQda3iWzCLA0K3Jxnzzw_gIAOBTFHtmLEMtFNSPtkTlf_776eYquta5Xg8ZkZS5H0ySLtbO9Cvbcqc3a6OQQA7reDCoYOyS2TcIak19XyUfVjeivDw5-2C72Oolr2yVnY-2DCSMOwT8k91rVeXy02_fJh5cv3i-O0tWb5avFwSrVueBZKvKCCmgyrpCWqChCpcqigBaaltVZw0XOeVbVUDFdokAlQDc1zXMObZlzne2TZ1PfjbOXcaoge-M1dp0a0I5elhmtRMUggvMJ1M5677CVG2d65baSgrwWK6NYeSs2Bp7sOo91j80tPpmM9ae7uvJada2LKo2_wQpW5YKWERMT9s10uP3PpfL49OyvEdIpa3zA7zdZ5b5IXmZlIT-dLOXr47e5WK7eyc-RryYeo_GvBp302mD84cY41EE21vzrtX8ATvu2vg</recordid><startdate>199206</startdate><enddate>199206</enddate><creator>Alvarez‐Builla, Julio</creator><creator>Crespo, Teresa</creator><creator>Lopez, Raquel</creator><creator>Elguero, Jose</creator><creator>Toiron, Catherine</creator><creator>Yranzo, Gloria I.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199206</creationdate><title>High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents</title><author>Alvarez‐Builla, Julio ; Crespo, Teresa ; Lopez, Raquel ; Elguero, Jose ; Toiron, Catherine ; Yranzo, Gloria I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4963-945190d36ae17ea1e08a7550f0df2b3d6946638b082c7e9ea90cdb14460f746c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Azoles - analysis</topic><topic>Azoles - chemistry</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Chromatography, High Pressure Liquid</topic><topic>General pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Regression Analysis</topic><topic>Spectrophotometry, Infrared</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alvarez‐Builla, Julio</creatorcontrib><creatorcontrib>Crespo, Teresa</creatorcontrib><creatorcontrib>Lopez, Raquel</creatorcontrib><creatorcontrib>Elguero, Jose</creatorcontrib><creatorcontrib>Toiron, Catherine</creatorcontrib><creatorcontrib>Yranzo, Gloria I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alvarez‐Builla, Julio</au><au>Crespo, Teresa</au><au>Lopez, Raquel</au><au>Elguero, Jose</au><au>Toiron, Catherine</au><au>Yranzo, Gloria I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1992-06</date><risdate>1992</risdate><volume>81</volume><issue>6</issue><spage>577</spage><epage>580</epage><pages>577-580</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H‐indazoles, 1H‐ and 2H‐benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>1522498</pmid><doi>10.1002/jps.2600810623</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0022-3549
ispartof Journal of pharmaceutical sciences, 1992-06, Vol.81 (6), p.577-580
issn 0022-3549
1520-6017
language eng
recordid cdi_proquest_miscellaneous_73189820
source Wiley Online Library Journals
subjects Azoles - analysis
Azoles - chemistry
Biological and medical sciences
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Regression Analysis
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
title High‐Performance Liquid Chromatographic Determination of the π Values of Azol‐N‐yl Substituents
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T15%3A32%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%E2%80%90Performance%20Liquid%20Chromatographic%20Determination%20of%20the%20%CF%80%20Values%20of%20Azol%E2%80%90N%E2%80%90yl%20Substituents&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Alvarez%E2%80%90Builla,%20Julio&rft.date=1992-06&rft.volume=81&rft.issue=6&rft.spage=577&rft.epage=580&rft.pages=577-580&rft.issn=0022-3549&rft.eissn=1520-6017&rft.coden=JPMSAE&rft_id=info:doi/10.1002/jps.2600810623&rft_dat=%3Cproquest_cross%3E73189820%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4963-945190d36ae17ea1e08a7550f0df2b3d6946638b082c7e9ea90cdb14460f746c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=73189820&rft_id=info:pmid/1522498&rfr_iscdi=true