Translocation (1;4)(p31;q34) in nonossifying fibroma

Nonossifying fibroma is a benign, lytic lesion of fibrous origin most often observed in the metaphyseal region of the long bones in children and adolescents. It is frequently asymptomatic and is often characterized by a history of spontaneous resolution. Herein, we report a clinicohistopathologicall...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2003-04, Vol.142 (2), p.142-144
Main Authors: Nelson, Marilu, Perry, Deborah, Ginsburg, Glen, Sanger, Warren G., Neff, James R., Bridge, Julia A.
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 4 - genetics
Diseases of the osteoarticular system
Female
Fibroma - genetics
Humans
Karyotyping
Knee - pathology
Medical sciences
Translocation, Genetic - genetics
Tumors of striated muscle and skeleton
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Summary:Nonossifying fibroma is a benign, lytic lesion of fibrous origin most often observed in the metaphyseal region of the long bones in children and adolescents. It is frequently asymptomatic and is often characterized by a history of spontaneous resolution. Herein, we report a clinicohistopathologically typical case of nonossifying fibroma arising in the tibia of an 18-year-old skeletally mature female. Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(02)00805-1