Anthropometric Status, Serum Prealbumin Level and Immune Response to Measles Vaccination in Mali Children

Summary Protein energy malnutrition (PEM) is known to depress cell-mediated immunity. Its effect on humoral immunity is less clear-cut. The purpose of the study was to assess seroconversion following measles vaccination according to child nutritional status as assessed by anthropometry and serum thy...

Full description

Saved in:
Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1992-08, Vol.38 (4), p.179-184
Main Authors: Dao, Halima, Delisle, Hélène, Fournier, Pierre
Format: Article
Language:English
Subjects:
Anthropometry
Biological and medical sciences
Female
Human viral diseases
Humans
Immunoglobulin G - immunology
Immunoglobulin M - immunology
Immunologic Techniques
Infant
Infant, Newborn
Infectious diseases
Male
Mali
Measles - diagnosis
Measles - immunology
Measles - prevention & control
Measles Vaccine - immunology
Medical sciences
Nutritional Status
Prealbumin - analysis
Protein-Energy Malnutrition - complications
Protein-Energy Malnutrition - immunology
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Protein energy malnutrition (PEM) is known to depress cell-mediated immunity. Its effect on humoral immunity is less clear-cut. The purpose of the study was to assess seroconversion following measles vaccination according to child nutritional status as assessed by anthropometry and serum thyroxinebinding prealbumin (TBPA). Prior to vaccination, 200 Malian children aged 8–22 months (mode: 9 months) and free of infection were weighed and measured. A venous blood sample was drawn for determination of serum TBPA by radial immunodiffusion and of measles specific immunoglobulins (Ig) by Enzyme-linked Immuno-Sorbent Assay (ELISA). IgG and IgM were again assayed 6 weeks post-vaccination after excluding pre-immune subjects. Seroconversion took place in 91 per cent of the children (95 per cent confidence interval: 86–96 per cent). Based on the NCHS standards, 30 per cent of the children were wasted (weight-for-height < −2.0 SD) and 18 per cent were stunted (height-for-age < −2.0 SD). Low serum TBPA (< 10 mg/dl) was found in 38 per cent of them. TBPA was significantly correlated with weight-for-height and weight-for-age(P
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/38.4.179