Bone metastases from osteosarcoma

Bony metastases in patients with osteosarcoma are unusual and normally appear late in the course of the disease. We report our experience with eight such patients, four with solitary and four with multiple metastases. Those with solitary metastases were treated as new tumours with neoadjuvant chemot...

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Bibliographic Details
Published in:International orthopaedics 2003, Vol.27 (2), p.117-120
Main Authors: SAN-JULIAN, M, DIAZ-DE-RADA, P, NOAIN, E, SIERRASESUMAGA, L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Bone Neoplasms - drug therapy
Bone Neoplasms - pathology
Bone Neoplasms - secondary
Bone Neoplasms - surgery
Child
Combined Modality Therapy
Diseases of the osteoarticular system
Humans
Medical sciences
Neoplasm Metastasis
Orthopedic Procedures
Orthopedic surgery
Osteosarcoma - drug therapy
Osteosarcoma - pathology
Osteosarcoma - secondary
Osteosarcoma - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Treatment Outcome
Tumors of striated muscle and skeleton
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Summary:Bony metastases in patients with osteosarcoma are unusual and normally appear late in the course of the disease. We report our experience with eight such patients, four with solitary and four with multiple metastases. Those with solitary metastases were treated as new tumours with neoadjuvant chemotherapy and surgery. Three remain alive with no evidence of disease at 5, 7 and 8 years follow-up respectively. Histology and response to neoadjuvant chemotherapy was similar in both the primary and metastatic lesions and is a predictive factor of outcome. Those with multiple metastases were treated by palliative measures, and none survived. We conclude that resection of solitary metastases from osteosarcoma after neoadjuvant chemotherapy can be curative.
ISSN:0341-2695
1432-5195
DOI:10.1007/s00264-002-0407-8