Autoimmune Identification of Sudden Hearing Loss

Objective-To identify autoantibody bands using Western blotting in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Material and Methods-All patients admitted to our emergency ward with ISSNHL during a 3-year period (n=51) were included in a diagnostic laboratory protocol, which...

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Bibliographic Details
Published in:Acta oto-laryngologica 2003-02, Vol.123 (2), p.169-171
Main Authors: García Callejo, F. J., Marco Algarra, J., Martínez Beneyto, M. P., Orts Alborch, M. H., Morant Ventura, A.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Audiometry - methods
Autoantibodies - analysis
Autoimmune Diseases - complications
Autoimmune Diseases - diagnosis
Biological and medical sciences
Blotting, Western
Cohort Studies
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Hearing Loss, Sensorineural - diagnosis
Hearing Loss, Sensorineural - drug therapy
Hearing Loss, Sensorineural - immunology
Hearing Loss, Sudden - diagnosis
Hearing Loss, Sudden - drug therapy
Hearing Loss, Sudden - immunology
Humans
idiopathic sudden sensorineural hearing loss
inner ear autoimmune disorder
laboratory diagnosis
Male
Medical sciences
Middle Aged
Multivariate Analysis
Non tumoral diseases
Otorhinolaryngology. Stomatology
Predictive Value of Tests
Probability
Prognosis
Regression Analysis
Sensitivity and Specificity
Western blot
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Summary:Objective-To identify autoantibody bands using Western blotting in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Material and Methods-All patients admitted to our emergency ward with ISSNHL during a 3-year period (n=51) were included in a diagnostic laboratory protocol, which included a non-specific test battery for immune disorders and a Western blot (WB) for bovine cochlear antigen, and underwent corticosteroid therapy. Results-In 16 cases (31%) a band was identified in the WB. Cases with a positive WB showed abnormal results in a greater number of non-specific laboratory tests (3.6±1.3 vs 0.9±1.1; p
ISSN:0001-6489
1651-2251
DOI:10.1080/0036554021000028101