Solution crystallisation via a submerged liquid-liquid phase boundary: oiling out

In many situations the process of crystallisation from solution is known to occur via metastable crystalline states (polymorphs or solvates). Here we present what we believe to be a novel example of small molecule crystallisation in which the initial separation of a solute rich liquid phase precedes...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2003-03 (6), p.698-699
Main Authors: Bonnett, P E, Carpenter, K J, Dawson, S, Davey, R J
Format: Article
Language:English
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Summary:In many situations the process of crystallisation from solution is known to occur via metastable crystalline states (polymorphs or solvates). Here we present what we believe to be a novel example of small molecule crystallisation in which the initial separation of a solute rich liquid phase precedes the crystallisation event. We believe this occurs because a submerged liquid-liquid phase boundary is accessible within the metastable zone of the crystal nucleation process.
ISSN:1359-7345
1364-548X
DOI:10.1039/b212062c