A topography and ultrastructural characterization of in vivo 5,7-dihydroxytryptamine-labeled serotonin-containing neurons in the central nervous system of Aplysia californica

1. Several weeks after administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia, a dark pigmentation appears in serotonin-containing neurons, and this pigmentation allows visual identification of serotonergic neurons but does not appear to alter their physiology. 2. We have determined the dist...

Full description

Saved in:
Bibliographic Details
Published in:Cellular and molecular neurobiology 1992-08, Vol.12 (4), p.317-326
Main Authors: HERNADI, L, ROZSA, K. S, JAHAN-PARWAR, B, CARPENTER, D. O
Format: Article
Language:English
Subjects:
5,7-Dihydroxytryptamine - pharmacokinetics
Animals
Aplysia - chemistry
Aplysia californica
Biochemistry. Physiology. Immunology
Biological and medical sciences
Central Nervous System - chemistry
Central Nervous System - cytology
Cytoplasmic Granules - ultrastructure
Fundamental and applied biological sciences. Psychology
Invertebrates
Microscopy, Electron
Mollusca
Neurons - chemistry
Neurons - ultrastructure
Oxidation-Reduction
Physiology. Development
Pigmentation
Serotonin - analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1. Several weeks after administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia, a dark pigmentation appears in serotonin-containing neurons, and this pigmentation allows visual identification of serotonergic neurons but does not appear to alter their physiology. 2. We have determined the distribution of labeled nerve cell bodies in the various ganglia of Aplysia and have characterized the pigment containing structures in both control and labeled neurons. 3. All neurons in this preparation, whether or not they utilize serotonin as a transmitter, contain pigment granules, and three types of pigment granules can be distinguished. After 5,7-DHT a new type of granule appears in serotonergic neurons, probably reflecting lysosomes that have accumulated serotonergic synaptic vesicles that contain the oxidized 5,7-DHT. 4. It remains unclear why this substance does not cause neurotoxicity in mollusks as it does in mammalian preparations.
ISSN:0272-4340
1573-6830
DOI:10.1007/BF00734932