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5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors
The evaluation of structure–activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described. The synthesis and inhibiting potency of farnesyltransferase inhibitors closely related to R115777 is reported.
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Published in: | Bioorganic & medicinal chemistry letters 2003-05, Vol.13 (9), p.1543-1547 |
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Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The evaluation of structure–activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
The synthesis and inhibiting potency of farnesyltransferase inhibitors closely related to R115777 is reported. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/S0960-894X(03)00180-X |