Uric acid and survival in chronic heart failure: Validation and application in metabolic, functional, and hemodynamic staging

Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). For the derivation study, 112 patients with CHF (age 59+/-12 years, peak oxygen consumption [Vo2] 17+/-7 mL/kg per minute) were recruited. In se...

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Published in:Circulation (New York, N.Y.) N.Y.), 2003-04, Vol.107 (15), p.1991-1997
Main Authors: ANKER, Stefan D, DOEHNER, Wolfram, SEGAL, Robert, OSTERZIEL, Karl Josef, LEYVA, Francisco, HETZER, Roland, PONIKOWSKI, Piotr, COATS, Andrew J. S, RAUCHHAUS, Mathias, SHARMA, Rakesh, FRANCIS, Darrel, KNOSALLA, Christoph, DAVOS, Constantinos H, CICOIRA, Mariantonietta, SHAMIM, Waqar, KEMP, Michel
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Chronic Disease
Comorbidity
Female
Follow-Up Studies
Heart
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hemodynamics
Humans
Hyperuricemia - blood
Hyperuricemia - diagnosis
Male
Medical sciences
Middle Aged
Models, Statistical
Oxygen Consumption
Predictive Value of Tests
Prognosis
Risk Factors
ROC Curve
Sensitivity and Specificity
Stroke Volume
Survival Rate
Uric Acid - blood
Xanthine Oxidase - metabolism
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Summary:Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). For the derivation study, 112 patients with CHF (age 59+/-12 years, peak oxygen consumption [Vo2] 17+/-7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 micromol/L (9.50 mg/dL) (independently of age, peak Vo2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea; Por=565 micromol/L predicted mortality (hazard ratio, 7.14; Por=565 micromol/L, left ventricular ejection fraction
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000065637.10517.A0