Thermal behaviour and binary phase diagram of ( S)-(+)-4,4′-(1-methyl-1,2-ethandiyl)-bis-(2,6-piper-azinedione) (dexrazoxane), a cardioprotective agent, and of its ( R)-(−)-enantiomer

The binary phase diagram of ( S)-(+)-4,4′-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione), 1 (dexrazoxane), a cardioprotective agent, and of its ( R)-(−)-enantiomer, 2 has been investigated by differential scanning calorimetry (DSC); the equimolecular mixture of 1 and 2 corresponds to a racemic c...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1992, Vol.10 (1), p.31-36
Main Authors: Vigevani, Aristide, Zampieri, Massimo, Pellizzato, Renato
Format: Article
Language:English
Subjects:
( S)-(+)-4,4′-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)
Algorithms
Antineoplastic agents
binary phase diagram
Biological and medical sciences
Calorimetry, Differential Scanning - methods
Cardiovascular Agents - chemistry
differential scanning calorimetry
enantiomeric purity
General aspects
IR spectroscopy
Medical sciences
Pharmacology. Drug treatments
polarimetry
Razoxane - chemistry
Stereoisomerism
Temperature
X-ray powder diffraction
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Summary:The binary phase diagram of ( S)-(+)-4,4′-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione), 1 (dexrazoxane), a cardioprotective agent, and of its ( R)-(−)-enantiomer, 2 has been investigated by differential scanning calorimetry (DSC); the equimolecular mixture of 1 and 2 corresponds to a racemic compound (racemate) whose melting point is higher than that of the enantiomers. Thermal behaviour (DSC) is examined and discussed in comparison with the data obtained by other physical methods (IR spectroscopy and X-ray powder diffraction).
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(92)80007-A