Soluble interleukin‐2 receptor serum levels in mycosis fungoides. Correlation with clinical stage

Background. In a variety of non‐Hodgkin lympho‐mas, a correlation between soluble interleukin‐2 receptor levels (sIL‐2R) and clinical stage is demonstrable. In mycosis fungoides (MF), two findings raise the question as to a similar correlation: (1) a proportion of tumor cells express IL‐2 receptor a...

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Bibliographic Details
Published in:Cancer 1992-11, Vol.70 (9), p.2338-2341
Main Authors: Szeimies, Rolf‐Markus, Rueff, Franziska, Kaudewitz, Peter
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
clinical staging
cutaneous T‐cell lymphoma
Dermatitis, Atopic - blood
Female
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
mycosis fungoides
Mycosis Fungoides - blood
Mycosis Fungoides - pathology
Neoplasm Staging
Receptors, Interleukin-2 - analysis
Skin Neoplasms - blood
Skin Neoplasms - pathology
soluble interleukin‐2 receptor
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Summary:Background. In a variety of non‐Hodgkin lympho‐mas, a correlation between soluble interleukin‐2 receptor levels (sIL‐2R) and clinical stage is demonstrable. In mycosis fungoides (MF), two findings raise the question as to a similar correlation: (1) a proportion of tumor cells express IL‐2 receptor and (2) sIL‐2R is detectable in serum. Methods. sIL‐2R were measured in patients with MF (n = 88) and atopic dermatitis (AD) (n = 14) by the enzyme immunoassay technique. Patients with AD served as controls. Cases of MF were classified according to the TNM staging classification. Results. Sera of patients with MF with stages 111, IVa, and IVb showed significantly higher values than those of stage I or I1 and controls. Conclusions. Although a close and significant correlation was found between sIL‐2R levels and stage of disease in MF, it is still not clear whether elevated sIL‐2R levels reflect disease activity or T‐cell activation due to concomitant immunologic processes. Cancer 1992; 70:2338‐2341.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19921101)70:9<2338::AID-CNCR2820700921>3.0.CO;2-T