Nonspecific Cell‐Mediated Immunity in Patients with Epidermodysplasia Verruciformis

Epidermodysplasia verruciformis (EV) is a rare disease that usually begins in childhood and is characterized by a generalized infection by human papilloma virus (HPV), frequent associations with cutaneous carcinomas, and abnormalities of cell‐mediated immunity (CMI). We studied nonspecific CMI in 13...

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Bibliographic Details
Published in:Journal of dermatology 2003-03, Vol.30 (3), p.203-209
Main Authors: Oliveira, Walmar Roncalli Pereira, Carrasco, Solange, Neto, Cyro Festa, Rady, Peter, Tyring, Stephen K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Case-Control Studies
CD4-CD8 Ratio
cell‐mediated immunity
Dinitrochlorobenzene - pharmacology
DNCB sensitization
epidermodysplasia verruciformis
Epidermodysplasia Verruciformis - complications
Epidermodysplasia Verruciformis - immunology
Female
human papilloma virus
Human papillomavirus
Humans
Immunity, Cellular - physiology
Immunization
Lymphocyte Activation - drug effects
lymphocyte transformation
Male
Papillomaviridae - isolation & purification
Papillomavirus Infections - complications
Papillomavirus Infections - immunology
Phytohemagglutinins - pharmacology
Prospective Studies
Rare Diseases
Sensitivity and Specificity
Skin Neoplasms - immunology
Skin Neoplasms - pathology
Skin Tests
Tumor Virus Infections - complications
Tumor Virus Infections - immunology
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Summary:Epidermodysplasia verruciformis (EV) is a rare disease that usually begins in childhood and is characterized by a generalized infection by human papilloma virus (HPV), frequent associations with cutaneous carcinomas, and abnormalities of cell‐mediated immunity (CMI). We studied nonspecific CMI in 13 patients with EV by bacterial skin tests, allergic reactions to dinitrochlorobenzene (DNCB), measurement of responses to phytohemagglutinin (PHA), and quantification of T lymphocytes and T lymphocytes subsets in peripheral blood. Impairment of CMI was manifested by the cutaneous anergy to a variety of common skin antigens and, by the reduction of the lymphocyte transformation to PHA. There were no correlation between the severity of cases and abnormalities of CMI in our patients, however; the impairment of CMI was lower in cases of short duration, suggesting that the impairment of CMI in EV might reflect a long period of disease.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2003.tb00372.x