A novel laminin B1 chain variant in avian eye

Two distinct recombinant cDNA clones having homology to mouse laminin B1 have been isolated from an adult chicken eye library by cross-species nucleic acid hybridization. DNA sequence analysis identified one cDNA as the chicken homologue of the prototypic EHS laminin B1 chain. The second recombinant...

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Bibliographic Details
Published in:The Journal of biological chemistry 1992-10, Vol.267 (29), p.20555-20557
Main Author: J J O'Rear
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
B1 chain
Base Sequence
Biological and medical sciences
cDNA
Chickens
Cloning, Molecular
DNA - genetics
DNA - isolation & purification
eye
Fundamental and applied biological sciences. Psychology
Gene Library
genes
Genetic Variation
Glycoproteins
Humans
laminin
Laminin - genetics
Molecular Sequence Data
nucleotide sequence
prediction
Proteins
Sequence Homology, Amino Acid
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Description
Summary:Two distinct recombinant cDNA clones having homology to mouse laminin B1 have been isolated from an adult chicken eye library by cross-species nucleic acid hybridization. DNA sequence analysis identified one cDNA as the chicken homologue of the prototypic EHS laminin B1 chain. The second recombinant cDNA encodes a portion of a laminin B1-like protein, which is neither the chicken homologue of laminin B1 nor s-laminin, and thus represents a new laminin B1 variant.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)36720-1