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A Case of Bullous Pemphigoid Successfully Treated by Plasmapheresis: Assessment of the Change in Titers of Circulating Antibodies by Immunoblotting and Enzyme‐Linked Immunosorbent Assay
We report a case of bullous pemphigoid successfully treated with double filtration plasmapheresis. The changes in titers of circulating autoantibodies were assessed by immunoblotting and enzyme‐linked immunosorbent assay (ELISA) using a recombinant protein of the non‐collagenous 16a (NC16a) domain o...
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| Published in: | Journal of dermatology 2003-04, Vol.30 (4), p.326-331 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4585-7e109c957c844b6a9bca76fa92e11f9c16877d80444102c2c61e88d20350ff533 |
| container_end_page | 331 |
| container_issue | 4 |
| container_start_page | 326 |
| container_title | Journal of dermatology |
| container_volume | 30 |
| creator | Lee, Jee Bum Fumimori, Takeaki Kurose, Koichiro Mori, Osamu Hashimoto, Takashi |
| description | We report a case of bullous pemphigoid successfully treated with double filtration plasmapheresis. The changes in titers of circulating autoantibodies were assessed by immunoblotting and enzyme‐linked immunosorbent assay (ELISA) using a recombinant protein of the non‐collagenous 16a (NC16a) domain of the 180 kDa bullous pemphigoid antigen (BP180). The ELISA was shown to be more sensitive in detecting disease‐specific antoantibodies in the bullous pemphigoid sera. The reduction of titers of circulating autoantibodies in the sera correlated well with the decrease in the disease activity in both the first and second rounds of plasmapheresis treatment in this case. |
| doi_str_mv | 10.1111/j.1346-8138.2003.tb00395.x |
| format | article |
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The changes in titers of circulating autoantibodies were assessed by immunoblotting and enzyme‐linked immunosorbent assay (ELISA) using a recombinant protein of the non‐collagenous 16a (NC16a) domain of the 180 kDa bullous pemphigoid antigen (BP180). The ELISA was shown to be more sensitive in detecting disease‐specific antoantibodies in the bullous pemphigoid sera. 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The changes in titers of circulating autoantibodies were assessed by immunoblotting and enzyme‐linked immunosorbent assay (ELISA) using a recombinant protein of the non‐collagenous 16a (NC16a) domain of the 180 kDa bullous pemphigoid antigen (BP180). The ELISA was shown to be more sensitive in detecting disease‐specific antoantibodies in the bullous pemphigoid sera. The reduction of titers of circulating autoantibodies in the sera correlated well with the decrease in the disease activity in both the first and second rounds of plasmapheresis treatment in this case.</description><subject>Autoantibodies - analysis</subject><subject>Autoantigens - analysis</subject><subject>bullous pemphigoid</subject><subject>Carrier Proteins</subject><subject>Collagen - analysis</subject><subject>Collagen Type XVII</subject><subject>Cytoskeletal Proteins</subject><subject>Dystonin</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>immunoblotting</subject><subject>Immunoblotting - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Tissue Proteins</subject><subject>Non-Fibrillar Collagens</subject><subject>Pemphigoid, Bullous - immunology</subject><subject>Pemphigoid, Bullous - therapy</subject><subject>plasmapheresis</subject><subject>Plasmapheresis - methods</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqVkc2O0zAUhS0EYjoDr4AsFohNi3-S2JkVJRQYVImRKGvLcW5al8Tp2ImYzIpH4H14G54EZ1rBDgkv7Cvf754j3YPQc0oWNJ5X-wXlSTaXlMsFI4Qv-jLeebq4fYBmf1oP0Yxwmc5ZQsQZOg9hTwjLU0oeozPKBBGJIDP0c4kLHQB3NX4zNE03BHwN7WFnt52t8OfBGAihjp0RbzzoHipcjvi60aHVhx14CDZc4mUIEWvB9ZNQvwNc7LTbArYOb2wPPkz_hfVmaHRv3RYvXW_LrrIQJr2rth1cVzZdf9_UrsIrdze28Ov7j7V1X6PrEQmdLyeXaKjHJ-hRrZsAT0_vBfrybrUpPszXn95fFcv13CRpXIAASnKTp8LIJCkznZdGi6zWOQNK69zQTApRSZIkCSXMMJNRkLJihKekrlPOL9CLo-7BdzcDhF61NhhoGu0gLkwJzhjjGYvgy3-CNM0ymQpJk4heHlHjuxA81Orgbav9qChRU8pqr6Yo1RSlmlJWp5TVbRx-dvIZyhaqv6OnWCPw-gh8sw2M_yGtPr5d3Zf8N1EVu48</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Lee, Jee Bum</creator><creator>Fumimori, Takeaki</creator><creator>Kurose, Koichiro</creator><creator>Mori, Osamu</creator><creator>Hashimoto, Takashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200304</creationdate><title>A Case of Bullous Pemphigoid Successfully Treated by Plasmapheresis: Assessment of the Change in Titers of Circulating Antibodies by Immunoblotting and Enzyme‐Linked Immunosorbent Assay</title><author>Lee, Jee Bum ; Fumimori, Takeaki ; Kurose, Koichiro ; Mori, Osamu ; Hashimoto, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4585-7e109c957c844b6a9bca76fa92e11f9c16877d80444102c2c61e88d20350ff533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Autoantibodies - analysis</topic><topic>Autoantigens - analysis</topic><topic>bullous pemphigoid</topic><topic>Carrier Proteins</topic><topic>Collagen - analysis</topic><topic>Collagen Type XVII</topic><topic>Cytoskeletal Proteins</topic><topic>Dystonin</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>immunoblotting</topic><topic>Immunoblotting - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Tissue Proteins</topic><topic>Non-Fibrillar Collagens</topic><topic>Pemphigoid, Bullous - immunology</topic><topic>Pemphigoid, Bullous - therapy</topic><topic>plasmapheresis</topic><topic>Plasmapheresis - methods</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jee Bum</creatorcontrib><creatorcontrib>Fumimori, Takeaki</creatorcontrib><creatorcontrib>Kurose, Koichiro</creatorcontrib><creatorcontrib>Mori, Osamu</creatorcontrib><creatorcontrib>Hashimoto, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jee Bum</au><au>Fumimori, Takeaki</au><au>Kurose, Koichiro</au><au>Mori, Osamu</au><au>Hashimoto, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Bullous Pemphigoid Successfully Treated by Plasmapheresis: Assessment of the Change in Titers of Circulating Antibodies by Immunoblotting and Enzyme‐Linked Immunosorbent Assay</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2003-04</date><risdate>2003</risdate><volume>30</volume><issue>4</issue><spage>326</spage><epage>331</epage><pages>326-331</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>We report a case of bullous pemphigoid successfully treated with double filtration plasmapheresis. The changes in titers of circulating autoantibodies were assessed by immunoblotting and enzyme‐linked immunosorbent assay (ELISA) using a recombinant protein of the non‐collagenous 16a (NC16a) domain of the 180 kDa bullous pemphigoid antigen (BP180). The ELISA was shown to be more sensitive in detecting disease‐specific antoantibodies in the bullous pemphigoid sera. The reduction of titers of circulating autoantibodies in the sera correlated well with the decrease in the disease activity in both the first and second rounds of plasmapheresis treatment in this case.</abstract><cop>England</cop><pmid>12707470</pmid><doi>10.1111/j.1346-8138.2003.tb00395.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of dermatology, 2003-04, Vol.30 (4), p.326-331 |
| issn | 0385-2407 1346-8138 |
| language | eng |
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| source | Wiley |
| subjects | Autoantibodies - analysis Autoantigens - analysis bullous pemphigoid Carrier Proteins Collagen - analysis Collagen Type XVII Cytoskeletal Proteins Dystonin Enzyme-Linked Immunosorbent Assay Follow-Up Studies Humans immunoblotting Immunoblotting - methods Male Middle Aged Nerve Tissue Proteins Non-Fibrillar Collagens Pemphigoid, Bullous - immunology Pemphigoid, Bullous - therapy plasmapheresis Plasmapheresis - methods Sensitivity and Specificity Severity of Illness Index Treatment Outcome |
| title | A Case of Bullous Pemphigoid Successfully Treated by Plasmapheresis: Assessment of the Change in Titers of Circulating Antibodies by Immunoblotting and Enzyme‐Linked Immunosorbent Assay |
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