Electrochemiluminescent Determination of L-Cysteine with a Flow-Injection Analysis System

A flow-injection electrochemiluminescent method for L-cysteine determination has been developed based on its enhancement of the electrochemiluminecence of luminol at a glassy carbon electrode. This method is simple and sensitive for cysteine determination. Under the selected experimental parameters,...

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Bibliographic Details
Published in:Analytical Sciences 2003, Vol.19(4), pp.575-578
Main Authors: ZHU, Liande, LI, Yingxiu, ZHU, Guoyi
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Cysteine - analysis
Electrochemistry - methods
Flow Injection Analysis - methods
General pharmacology
Luminescent Measurements
Medical sciences
Pharmacology. Drug treatments
Sensitivity and Specificity
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Summary:A flow-injection electrochemiluminescent method for L-cysteine determination has been developed based on its enhancement of the electrochemiluminecence of luminol at a glassy carbon electrode. This method is simple and sensitive for cysteine determination. Under the selected experimental parameters, the linear range for cysteine concentration was 1.0 × 10-6 - 5.0 × 10-5 mol/l, and the detection limit was 0.67 μmol/l (S/N = 3). The relative standard deviation for 11 measurements of 1.0 × 10-5 mol/l cysteine was 4.5%. The proposed method has been applied to the detection of cysteine in pharmaceutical injections with satisfactory results.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.19.575