THROMBELASTOGRAPHY AFTER ASPIRIN INGESTION IN PREGNANT AND NON-PREGNANT SUBJECTS

The thrombelastograph (TEG) and bleeding time were performed before and 6 h after a single oral dose of aspirin 600 mg in a group of eight healthy volunteers and 12 pregnant patients. Measured TEG variables (r, k, r + k times and maximum amplitude) were unaltered after aspirin although there was a s...

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Bibliographic Details
Published in:British Journal of Anaesthesia 1992-08, Vol.69 (2), p.159-161
Main Authors: ORLIKOWSKI, C.E.P., PAYNE, A.J., MOODLEY, J., ROCKE, D.A.
Format: Article
Language:English
Subjects:
Aspirin - administration & dosage
Aspirin - pharmacology
Biological and medical sciences
Bleeding Time
Blood Coagulation - drug effects
Blood Platelets - drug effects
Blood. Blood coagulation. Reticuloendothelial system
Blood: coagulation. Pregnancy aspirin therapy
Female
Humans
Measurement techniques: thrombelastography
Medical sciences
Pharmacology. Drug treatments
Pregnancy - blood
Thrombelastography
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Summary:The thrombelastograph (TEG) and bleeding time were performed before and 6 h after a single oral dose of aspirin 600 mg in a group of eight healthy volunteers and 12 pregnant patients. Measured TEG variables (r, k, r + k times and maximum amplitude) were unaltered after aspirin although there was a significant prolongation of the bleeding time in both groups. Although the TEG appeared not to detect aspirin-induced changes in platelet function, the TEG measures all phases of coagulation and the unaltered TEG after aspirin suggested a functioning coagulation system.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/69.2.159