Dark induction of haem oxygenase messenger RNA by haematoporphyrin derivative and zinc phthalocyanine; agents for photodynamic therapy

Haematoporphyrin derivative is one of the main drugs currently used in clinical trials involving photodynamic therapy of cancer, and zinc phthalocyanine is being considered as one of several possible alternatives. We show that incubation of cultured human fibroblasts populations with either of the t...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1992-07, Vol.14 (4), p.311-318
Main Authors: Bressoud, D., Jomini, V., Tyrrell, R.M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Line
Darkness
Fibroblasts - drug effects
Fibroblasts - metabolism
haem oxygenase
haematoporphyrin derivative
Hematoporphyrin Derivative - pharmacology
Heme Oxygenase (Decyclizing) - biosynthesis
Heme Oxygenase (Decyclizing) - genetics
Humans
Indoles - pharmacology
Kinetics
Light
Medical sciences
Organometallic Compounds - pharmacology
Photochemotherapy
photodynamic therapy
Photoradiation therapy and photosensitizing agent
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Skin - drug effects
Skin - metabolism
Transcription, Genetic - drug effects
Treatment with physical agents
Treatment. General aspects
Tumors
Zinc - pharmacology
zinc phthalocyanine
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Summary:Haematoporphyrin derivative is one of the main drugs currently used in clinical trials involving photodynamic therapy of cancer, and zinc phthalocyanine is being considered as one of several possible alternatives. We show that incubation of cultured human fibroblasts populations with either of the two drugs will lead to a sharp increase in the accumulation of the messenger RNA corresponding to haem oxygenase. Only cells incubated with haematoporphyrin derivative show additional enhancement of expression of this specific gene on exposure to red light. Since haem oxygenase induction appears to be a specific stress response that may be involved in cellular defence, such observations should be confirmed under conditions which would allow the clinical implications to be fully evaluated.
ISSN:1011-1344
1873-2682
DOI:10.1016/1011-1344(92)85110-G