Impaired Renal Vascular Reactivity in Prehypertensive Dahl Salt-Sensitive Rats

We have previously shown that renal vascular resistance is less in Dahl salt-sensitive rats than salt-resistant rats fed 1% NaCl diets; however, renal vascular resistance increases before nonrenal vascular resistance as salt-sensitive rats develop hypertension when fed 8% NaCl diets. When saltresist...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-10, Vol.20 (4), p.524-532
Main Authors: Simchon, Shlomoh, Manger, William M, Shi, Guo-Shan, Brensilver, Jeffrey
Format: Article
Language:English
Subjects:
Angiotensin II - pharmacology
Animals
Arterial hypertension. Arterial hypotension
Atrial Natriuretic Factor - pharmacology
Biological and medical sciences
Blood and lymphatic vessels
Cardiac Output - drug effects
Cardiology. Vascular system
Endothelins - pharmacology
Experimental diseases
Hypertension - etiology
Male
Medical sciences
Nitroprusside - pharmacology
Norepinephrine - pharmacology
Rats
Rats, Inbred Strains
Renal Circulation - drug effects
Vascular Resistance - drug effects
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Summary:We have previously shown that renal vascular resistance is less in Dahl salt-sensitive rats than salt-resistant rats fed 1% NaCl diets; however, renal vascular resistance increases before nonrenal vascular resistance as salt-sensitive rats develop hypertension when fed 8% NaCl diets. When saltresistant rats are given 8% NaCl diets, renal vascular resistance decreases. The current study reports effects of atrial natriuretic peptide, nitroprusside, norepinephrine, angiotensin II, and endothelin-1 on renal and nonrenal vascular resistance in prehypertensive salt-sensitive and salt-resistant rats given 1% NaCl diets; doses used did not affect blood pressure. Resistance of nonrenal vessels in salt-sensitive and salt-resistant rats responded similarly to dilators or constrictors. However, atrial natriuretic peptide and nitroprusside decreased renal vascular resistance of salt-resistant rats (by 65%, p< 0.01) but not that of salt-sensitive rats. Noreplnephrine, angiotensin H, and endothelin-1 increased renal vascular resistance in salt-sensitive rats by 126%, 135%, and 135%, respectively (p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.20.4.524