Experimental Infection of Equine Herpesvirus 9 in Dogs

Equine herpesvirus 9 (EHV-9), a new neurotropic equine herpesvirus, was inoculated intranasally at 107 plaque-forming units in five dogs to assess its pathogenicity. Dogs showed weight loss, pyrexia, anorexia, and neurologic signs on the fourth day. The EHV-9 virus was recovered from the examined br...

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Bibliographic Details
Published in:Veterinary pathology 2003-05, Vol.40 (3), p.263-267
Main Authors: Yanai, T., Fujishima, N., Fukushi, H., Hirata, A., Sakai, H., Masegi, T.
Format: Article
Language:English
Subjects:
Animals
Antigens, Viral - metabolism
Body Temperature
Brain - pathology
Brain - virology
Dog Diseases - pathology
Dog Diseases - virology
Dogs
Encephalitis - pathology
Encephalitis - veterinary
Encephalitis - virology
Herpesviridae Infections - pathology
Herpesviridae Infections - veterinary
Herpesviridae Infections - virology
Immunohistochemistry - veterinary
Lung - pathology
Lung - virology
Lymph Nodes - pathology
Lymph Nodes - virology
Male
Varicellovirus - pathogenicity
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Summary:Equine herpesvirus 9 (EHV-9), a new neurotropic equine herpesvirus, was inoculated intranasally at 107 plaque-forming units in five dogs to assess its pathogenicity. Dogs showed weight loss, pyrexia, anorexia, and neurologic signs on the fourth day. The EHV-9 virus was recovered from the examined brains. Histologically, dogs had a fulminant nonsuppurative encephalitis characterized by severe neuronal degeneration and loss, with intranuclear inclusions, slight glial reactions, perivascular cuffing, and multifocal hemorrhage. The olfactory bulb and the frontal and temporal lobes were predominantly affected. Immunohistochemistry revealed reactivity for EHV-9 antigen in neurons. All dogs had mild bronchopneumonia and various degrees of lymphoid necrosis. These findings indicate that dogs are fully susceptible to EHV-9 and that EHV-9 can cause fulminant encephalitis with high mortality in dogs, as in gazelles and goats.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.40-3-263