Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe

The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients....

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Bibliographic Details
Published in:Stroke (1970) 2003-05, Vol.34 (5), p.1207-1211
Main Authors: HOFER, Anne, HERMANS, Marcella, SCHOCH, Beate, WANKE, Isabel, HÜBNER, Felix, DEINSBERGER, Wolfgang, MEYER, Bernhard, BOECHER-SCHWARZ, Hans, POEWE, Werner, RAABE, Andreas, STEINMETZ, Helmuth, AUBURGER, Georg, KUBASSEK, Nina, SITZER, Matthias, FUNKE, Harald, STÖGBAUER, Florian, IVASKEVICIUS, Vytautas, OLDENBURG, Johannes, BURTSCHER, Johannes, KNOPP, Ulrich
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Alleles
Aneurysm, Ruptured - complications
Aneurysm, Ruptured - epidemiology
Austria - epidemiology
Biological and medical sciences
Chromatography, High Pressure Liquid
DNA Mutational Analysis
Elastin - genetics
Female
Genetic Heterogeneity
Genetic Predisposition to Disease
Germany - epidemiology
Haplotypes - genetics
Humans
Intracranial Aneurysm - epidemiology
Intracranial Aneurysm - genetics
Japan - epidemiology
Male
Medical sciences
Middle Aged
Neurology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Rupture, Spontaneous
Subarachnoid Hemorrhage - epidemiology
Subarachnoid Hemorrhage - etiology
Subarachnoid Hemorrhage - genetics
Vascular diseases and vascular malformations of the nervous system
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Description
Summary:The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients. We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls. We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm. Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000069013.83336.1C