Simple Method of Paroxetine Determination Using a Single Channel FIA with No In-line Reaction Process

A flow-injection analysis (FIA) of paroxetine hydrochloride (PRX), a selective serotonin reuptake inhibitor (SSRI) currently used as an antidepressant drug, is described. A 0.1 mol dm-3 acetate buffer at pH 3.07 was found to be the best solvent. The analyte was detected at 293 nm. The calibration eq...

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Bibliographic Details
Published in:Analytical Sciences 2003, Vol.19(4), pp.629-631
Main Authors: ALTIOKKA, Göksel, KIRCALI, Kevser
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Calibration
Flow Injection Analysis
General pharmacology
Medical sciences
Paroxetine - analysis
Pharmacology. Drug treatments
Reproducibility of Results
Sensitivity and Specificity
Serotonin Uptake Inhibitors - analysis
Spectrophotometry, Ultraviolet
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Description
Summary:A flow-injection analysis (FIA) of paroxetine hydrochloride (PRX), a selective serotonin reuptake inhibitor (SSRI) currently used as an antidepressant drug, is described. A 0.1 mol dm-3 acetate buffer at pH 3.07 was found to be the best solvent. The analyte was detected at 293 nm. The calibration equation was linear over the range of 1.07×10-6 to 5.35×10-6 mol dm-3. The limit of detection (LOD) and the limit of quantitation (LOQ) were 3.2×10-7 and 9.5×10-7 mol dm-3, respectively. The proposed method was applied to the determination of PRX in pharmaceutical preparations. The results were compared with those obtained by a conventional batchwise UV-spectrophotometry.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.19.629