Manipulation of the mouse genome: a multiple impact resource for drug discovery and development

Few would deny that the pharmaceutical industry's investment in genomics throughout the 1990s has yet to deliver in terms of drugs on the market. The reasons are complex and beyond the scope of this review. The unique ability to manipulate the mouse genome, however, has already had a positive i...

Full description

Saved in:
Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2003-05, Vol.21 (5), p.224-232
Main Authors: Prosser, Haydn, Rastan, Sohaila
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
Drug Design
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling - methods
Gene Expression Regulation - genetics
Genetic engineering
Genetic Engineering - methods
Genetic technics
Genome
Genomics
Genomics - methods
Humans
Methods. Procedures. Technologies
Mice
Mice, Transgenic - genetics
Mice, Transgenic - metabolism
Mutation
Pharmaceutical industry
R&D
Research & development
Rodents
Transgenic animals
Transgenic animals and transgenic plants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Few would deny that the pharmaceutical industry's investment in genomics throughout the 1990s has yet to deliver in terms of drugs on the market. The reasons are complex and beyond the scope of this review. The unique ability to manipulate the mouse genome, however, has already had a positive impact on all stages of the drug discovery process and, increasingly, on the drug development process too. We give an overview of some recent applications of so-called ‘transgenic’ mouse technology in pharmaceutical research and development. We show how genetic manipulation in the mouse can be employed at multiple points in the drug discovery and development process, providing new solutions to old problems.
ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(03)00087-8