Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccine in Allogeneic Bone Marrow Recipients

A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus injluenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before...

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Bibliographic Details
Published in:The Journal of infectious diseases 1992-11, Vol.166 (5), p.1021-1028
Main Authors: Barra, Anne, Cordonnier, Catherine, Preziosi, Marie-Pierre, Intrator, Liliane, Hessel, Luc, Fritzell, Bernard, Preud'homme, Jean-Louis
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibody formation
Bacterial Vaccines - immunology
Bacterial Vaccines - therapeutic use
Bone marrow
Bone Marrow Transplantation - immunology
Conjugate vaccines
Female
Follow-Up Studies
Haemophilus Infections - immunology
Haemophilus Infections - prevention & control
Haemophilus influenzae
Haemophilus influenzae - immunology
Haemophilus influenzae type b
Humans
Immunization
Immunoglobulin G - blood
Infections
Major Articles
Male
Polysaccharides
Polysaccharides, Bacterial - immunology
Tetanus Toxoid - immunology
Tetanus Toxoid - therapeutic use
Tissue grafting
Transplantation, Homologous
Vaccination
Vaccines, Synthetic - immunology
Vaccines, Synthetic - therapeutic use
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Summary:A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus injluenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before immunization, 3 patients had serum antibody levels > 1 µg/mL. After the first injection, the response was better after Hib-CPS-T than after Hib-CPS but lower than in normal subjects; a number of patients lacked any IgG antibody response, especially after Hib-CPS. Of patients who received two injections of Hib-CPS-T, 85% achieved an antibody concentration ⩾1 µg/mL. Hib-CPS-T induced a response in IgG2-deficient patients whereas Hib-CPS alone did not. IgG antibodies predominantly belonged to the IgG1 subclass. The antibody response was better in patients immunized late after graft. This study shows that Hib-CPS-T is more immunogenic than Hib-CPS in marrow recipients.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/166.5.1021