Activation-Induced Cytidine Deaminase Links Class Switch Recombination and Somatic Hypermutation

: Activation‐induced cytidine deaminase (AID), a putative RNA‐editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes—namely, class switch recombination, somatic hypermutation, and gene con...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2003-04, Vol.987 (1), p.1-8
Main Authors: OKAZAKI, ILMI, YOSHIKAWA, KIYOTSUGU, KINOSHITA, KAZUO, MURAMATSU, MASAMICHI, NAGAOKA, HITOSHI, HONJO, TASUKU
Format: Article
Language:English
Subjects:
activation-induced cytidine deaminase
Cell Line
class switch recombination
Cytidine Deaminase - biosynthesis
Cytidine Deaminase - genetics
Cytidine Deaminase - metabolism
Enzyme Activation
Enzyme Induction
gene conversion
Models, Biological
Mutation
Recombination, Genetic
S regions
somatic hypermutation
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Summary:: Activation‐induced cytidine deaminase (AID), a putative RNA‐editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes—namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure of the S and V region DNA is recognized by a nicking enzyme regulated by the putative RNA‐editing activity of AID.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2003.tb06027.x