Isoxazole-based derivatives from Baylis–Hillman chemistry: assessment of preliminary hypolipidemic activity

The synthesis of isoxazole-based derivatives utilizing Baylis–Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described. The synthesis of isoxazole-based derivatives utilizing Baylis–Hillman chemistry and results of their preliminary bioev...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2003-05, Vol.11 (10), p.2269-2276
Main Authors: Patra, A, Batra, S, Bhaduri, A.P, Khanna, A, Chander, R, Dikshit, M
Format: Article
Language:English
Subjects:
Acetals - chemistry
Acrylamides - chemistry
Amides - chemistry
Animals
Biological and medical sciences
Combinatorial Chemistry Techniques
Commiphora
Drug Evaluation, Preclinical
Fibrinolytic Agents - pharmacology
General and cellular metabolism. Vitamins
Hypolipidemic Agents - chemical synthesis
Hypolipidemic Agents - pharmacology
Isoxazoles - chemical synthesis
Isoxazoles - pharmacology
Lipids - blood
Medical sciences
Mice
Pharmacology. Drug treatments
Plant Extracts - therapeutic use
Plant Gums
Rats
Stereoisomerism
Structure-Activity Relationship
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Summary:The synthesis of isoxazole-based derivatives utilizing Baylis–Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described. The synthesis of isoxazole-based derivatives utilizing Baylis–Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents are described.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(03)00105-6