Antifungal activity of a thiophene polyine from Leuzea carthamoides

The thiophene polyine ( E)-2-[5-(hept-5-en-1,3-diynyl)-thien-2-yl]-ethan-1,2-diol was isolated from an ethanolic extract of underground parts of Leuzea carthamoides. The thiophene polyine demonstrated significant antifungal activity against all tested species.

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Bibliographic Details
Published in:Fitoterapia 2003-04, Vol.74 (3), p.288-290
Main Authors: Chobot, V., Buchta, V., Jahodářová, H., Pour, M., Opletal, L., Jahodář, L., Harant, P.
Format: Article
Language:English
Subjects:
Absidia - drug effects
Antifungal activity
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Aspergillus - drug effects
Asteraceae
Biological and medical sciences
Candida - drug effects
General pharmacology
Humans
Leuzea carthamoides
Medical sciences
Microbial Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Thiophene polyine
Thiophenes - administration & dosage
Thiophenes - pharmacology
Thiophenes - therapeutic use
Trichophyton - drug effects
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Description
Summary:The thiophene polyine ( E)-2-[5-(hept-5-en-1,3-diynyl)-thien-2-yl]-ethan-1,2-diol was isolated from an ethanolic extract of underground parts of Leuzea carthamoides. The thiophene polyine demonstrated significant antifungal activity against all tested species.
ISSN:0367-326X
DOI:10.1016/S0367-326X(03)00027-3