Prevention of macrophage-related inflammatory diseases by allergina

The oriental herbal combination allergina has been shown to inhibit allergic inflammation. In the present study, we demonstrate that the oral administration of allergina markedly inhibits the progression of inflammatory diseases, such as graft-versus-host diseases (in the allogeneic bone marrow tran...

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Bibliographic Details
Published in:Archives of pharmacal research 2003-04, Vol.26 (4), p.312-316
Main Authors: Han, Sang B, Lee, Chang W, Park, Song K, Yoon, Won K, Moon, Jae S, Lee, Ki H, Kim, Hyung C, Kim, Hwan M
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Arthritis, Experimental - drug therapy
Arthritis, Experimental - prevention & control
Collagen Type II - administration & dosage
Graft vs Host Disease - drug therapy
Graft vs Host Disease - prevention & control
Inflammation - drug therapy
Inflammation - pathology
Inflammation - prevention & control
Lipopolysaccharides - adverse effects
Macrophages - pathology
Male
Medicine, East Asian Traditional
Mice
Mice, Inbred DBA
Phytotherapy
Plant Extracts - therapeutic use
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - drug effects
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Summary:The oriental herbal combination allergina has been shown to inhibit allergic inflammation. In the present study, we demonstrate that the oral administration of allergina markedly inhibits the progression of inflammatory diseases, such as graft-versus-host diseases (in the allogeneic bone marrow transplantation and the parent-into-F1 transplantation models), collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity. The immunosuppressive activity of allergina in vivo appears to be associated, at least in part, with the inhibition of tumor necrosis factor-alpha production. In conclusion, our results suggest that allergina could be useful as a immunosuppressive agent for the treatment of macrophage-related inflammatory disease.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02976961