Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation

Osteoporosis is caused by an imbalance between bone resorption and formation which results in an absolute reduction in bone mass. In a previous study we highlighted a condition, osteoarthritis of the hip (coxarthrosis, cOA), where an imbalance between resorption and formation provided beneficial eff...

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Bibliographic Details
Published in:Osteoporosis international 2003-02, Vol.14 (2), p.160-165
Main Authors: JORDAN, G. R, LOVERIDGE, N, POWER, J, CLARKE, M. T, REEVE, J
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arthritis
Biological and medical sciences
Biopsy
Bone and Bones - physiopathology
Bone diseases
Bone Resorption - physiopathology
Diseases of the osteoarticular system
Female
Femur Neck - physiopathology
Fractures
Hip joint
Humans
Male
Medical sciences
Middle Aged
Osteoarthritis
Osteoarthritis, Hip - physiopathology
Osteogenesis - physiology
Osteoporosis
Osteoporosis. Osteomalacia. Paget disease
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Summary:Osteoporosis is caused by an imbalance between bone resorption and formation which results in an absolute reduction in bone mass. In a previous study we highlighted a condition, osteoarthritis of the hip (coxarthrosis, cOA), where an imbalance between resorption and formation provided beneficial effects in the form of an absolute increase in bone mass. We demonstrated that the femoral neck in patients with cOA had increased cancellous bone area, connectivity and trabecular thickness which might contribute to the protection against fracture associated with the condition. The aim of the present study was to analyze forming and resorbing surfaces in coxarthritic cancellous bone to assess whether increased formation or reduced resorption could be responsible for these structural changes. Whole cross-sectional femoral neck biopsies were obtained from 11 patients with cOA and histomorphometric parameters compared with 14 age- and sex-matched cadaveric controls. The ratio of osteoid surface to bone surface was 121% ( p
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-002-1351-6