Cartilaginous metaplasia in calcified diabetic peripheral vascular disease: Morphologic evidence of enchondral ossification

The mechanism of arterial calcification is not clear. We examined histological sections of major arteries from lower extremities of two patients with longstanding type II (or non-insulin-dependent) diabetes mellitus, and found morphological evidence of cartilaginous metaplasia and ectopic ossificati...

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Bibliographic Details
Published in:Human pathology 2003-04, Vol.34 (4), p.402-407
Main Authors: QIAO, Jian-Hua, MERTENS, Richard B, FISHBEIN, Michael C, GELLER, Stephen A
Format: Article
Language:English
Subjects:
Arteries - metabolism
Arteries - pathology
Arteriosclerosis - complications
Arteriosclerosis - metabolism
Arteriosclerosis - pathology
Associated diseases and complications
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Calcinosis - complications
Calcinosis - metabolism
Calcinosis - pathology
Cardiology. Vascular system
Cartilage - pathology
Collagen Type II - metabolism
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Extracellular Matrix Proteins - metabolism
Humans
Immunoenzyme Techniques
Leg
Male
Medical sciences
Metaplasia
Middle Aged
Ossification, Heterotopic - complications
Ossification, Heterotopic - metabolism
Ossification, Heterotopic - pathology
Peripheral Vascular Diseases - complications
Peripheral Vascular Diseases - metabolism
Peripheral Vascular Diseases - pathology
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Summary:The mechanism of arterial calcification is not clear. We examined histological sections of major arteries from lower extremities of two patients with longstanding type II (or non-insulin-dependent) diabetes mellitus, and found morphological evidence of cartilaginous metaplasia and ectopic ossification with associated severe medial arterial calcification and atherosclerosis. Hematoxylin and eosin, alcian blue, and toluidine blue stains were applied for the demonstration of cartilage cells and their specific matrix proteins, and immunohistochemical studies for type II collagen. To our knowledge, cartilaginous metaplasia has not previously been described in medium-sized human muscular arteries. This observation supports the hypothesis that active enchondral ossification may be a pathway leading to arterial calcification in diabetic obstructive peripheral vascular disease.
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2003.72