Changes in antigenic characteristics of erythrocytes and number metaphase chromosome in bone marrow cells after experimental and clinical bone marrow transplantation

Transplantation of allogenic bone marrow from HLA-identical sibs to patients with acute and chronic leukemia receiving immunosuppressive therapy is associated with the appearance of erythrocytes simultaneously carrying donor and recipient antigenic markers: AB0 system, rhesus factor and its subtypes...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-01, Vol.135 (1), p.73-76
Main Authors: Babaeva, A G, Kurilo, L F, Zotikov, E A, Belan, E I, Poreshina, L P, Yudina, N V
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - pathology
Bone Marrow Transplantation - adverse effects
Epitopes - immunology
Erythrocytes - immunology
Erythrocytes - ultrastructure
Female
Humans
Hybrid Cells - immunology
Hybrid Cells - ultrastructure
Leukemia - immunology
Leukemia - therapy
Metaphase - immunology
Mice
Mice, Inbred CBA
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transplantation of allogenic bone marrow from HLA-identical sibs to patients with acute and chronic leukemia receiving immunosuppressive therapy is associated with the appearance of erythrocytes simultaneously carrying donor and recipient antigenic markers: AB0 system, rhesus factor and its subtypes, M and N antigens. Integration of genes responsible for each antigen is realized independently presumably at the level of stem cell, which ensures long-term (>3 years) repopulation of these erythrocytes. Experiments on inbred mice showed that transplantation of allogenic bone marrow is associated with an increase of chromosome number in 39% bone marrow cells 4 days after transplantation, which indicate the possibility of integration of whole chromosomes.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1023458215408