Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica

• Published in: Journal of ethnopharmacology 2003-06, Vol.86 (2), p.177-180
• Main Authors: Rahman, Atta-ur, Nasim, Shama, Baig, Irfan, Jalil, Saima, Orhan, Ilkay, Sener, Bilge, Choudhary, M.Iqbal
• Format: Article
• Language: English
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-inflammatory assay; Biological and medical sciences; General pharmacology; Humans; Iridaceae; Iris germanica L; Iris Plant; Isoflavones; Isoflavones - chemistry; Isoflavones - isolation & purification; Isoflavones - pharmacology; Medical sciences; Medicine, Traditional; Neutrophils - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Preparations - chemistry; Plant Preparations - isolation & purification; Plant Preparations - pharmacology; Rhizome; Spectrophotometry; Structure-Activity Relationship
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(03)00055-2

The anti-inflammatory activity of nine isoflavonoids 5,7-dihydroxy-3-(3′-hydroxy-4′,5′dimethoxy)-8-methoxy-4 H-1-benzopyran-4-one 1, 5,7-dihydroxy-3-(3′-hydroxyl-4′, 5′-dimethoxy)-6-methoxy-4 H-1-benzopyran-4-one 2, 5, 7-dihydroxy-3-(4′-hydroxy)-6-methoxy-4 H-1-benzopyrane-4-one 3, 5-hydroxy-3-(4′-hydroxy)-6,7-methylenedioxy-4 H-1-benzopyran-4-one 4, 5-hydroxy-3-(4′-methoxy)-6,7-methylenedioxy-4 H-1-benzopyran-4-one 5, 5-methoxy-3-(4′-hydroxy)-6,7-methyenedioxy-4 H-1-benzopyran-4-one 6, 5,7-dihydroxy-3-(3′-hydroxy-4′-methoxy)-6-methoxy-4 H-1-benzopyran-4-one 7, 5,7-dihydroxy-3-(3′-methoxy-4′-hydroxy)-6-methoxy-4 H-1-benzopyran-4-one 8, and isopeonol 9 determined by a spectrophotometric assay using the activated human neurtrophilis. These isoflavonoids were isolated from an important folkloric medicinal plant Irsa ( Iris germanica L.), a member of the family Iridaceae. Structures of these compounds were identified by spectral comparison with the reported data and active members of this group adds into the growing number of non-steroidal anti-inflammatory agents.