Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane ( γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was e...

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Bibliographic Details
Published in:Biomaterials 2003-08, Vol.24 (17), p.2889-2894
Main Authors: Yoshioka, Tomohiko, Tsuru, Kanji, Hayakawa, Satoshi, Osaka, Akiyoshi
Format: Article
Language:English
Subjects:
Alginates - chemistry
Alginic acid
Biotechnology - methods
Blood
Blood Coagulation Factors - metabolism
Blood compatibility
Blood-clotting time
Cells, Cultured
Coated Materials, Biocompatible - chemical synthesis
Coated Materials, Biocompatible - chemistry
Fibrinogen - metabolism
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Humans
Materials Testing
Plasma - metabolism
Platelet Activation
Platelet adhesion
Platelet Adhesiveness - physiology
Prostheses and Implants
Prothrombin - metabolism
Stainless steel
Stainless Steel - chemistry
Surface Properties
Thromboplastin - metabolism
γ-Aminopropyltriethoxysilane
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Summary:This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane ( γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(03)00127-3