Pathogenicity differences of multiple isolates of Aspergillus fumigatus in turkeys

Sixteen Aspergillus fumigatus isolates of environmental, mammalian, and avian origin were used to assess: 1) intra-air-sac inoculation as a viable challenge alternative to aerosol exposure, and 2) isolate variability in pathogenicity. Development of lesions, antibody response in survivors, mortality...

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Bibliographic Details
Published in:Avian diseases 1992-07, Vol.36 (3), p.537-542
Main Authors: Peden, W.M. (USDA, ARS, Avian Diseases Research Unit, Ames, IA), Rhoades, K.R
Format: Article
Language:English
Subjects:
Aerosols
ANIMALES JOVENES
Animals
Antibodies, Fungal - immunology
Antigens
Aspergillosis
Aspergillosis - mortality
Aspergillosis - veterinary
ASPERGILLUS FUMIGATUS
Aspergillus fumigatus - pathogenicity
Body Weight
Conidia
DINDON
Enzyme-Linked Immunosorbent Assay
EXPERIMENTACION IN VIVO
EXPERIMENTATION IN VIVO
GAIN DE POIDS
GANANCIA DE PESO
Immunodiffusion - veterinary
INFECCION
INFECTION
JEUNE ANIMAL
LESION
LESIONES
Lesions
Lung Diseases, Fungal - pathology
Lung Diseases, Fungal - veterinary
Lungs
MORTALIDAD
MORTALITE
Mortality
PAVO
PODER PATOGENO
Poultry Diseases - microbiology
Poultry Diseases - mortality
Poults
POUVOIR PATHOGENE
Pulmonary alveoli
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
Turkeys
Turkeys - microbiology
Virulence
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Summary:Sixteen Aspergillus fumigatus isolates of environmental, mammalian, and avian origin were used to assess: 1) intra-air-sac inoculation as a viable challenge alternative to aerosol exposure, and 2) isolate variability in pathogenicity. Development of lesions, antibody response in survivors, mortality, and weight gains were assessed. Turkey poults were challenged with equal numbers of viable conidia. Total number of conidia given per experimental group varied markedly and did not influence mortality. Antibody response as measured by the enzyme-linked-immunosorbent assay and agar gel immunodiffusion test was erratic, although most poults with high antibody scores had marked lesions and low weight. Lesions were characterized by necrogranulomatous pneumonia and airsacculitis with marked visceral involvement. The source of the isolate was not a factor in mortality, although this was biased by the high numbers of isolates from birds with aspergillosis. The single environmental isolate produced no mortality
ISSN:0005-2086
1938-4351
DOI:10.2307/1591746