Role of profilin and polcalcin in chenopod pollen allergy

Sensitization to Chenopodiaceae is highly concomitant with other, more ubiquitous pollinosis; thus, patients allergic to chenopod are frequently polysensitized. [...]several studies have shown a high degree of cross-reactivity between chenopod pollen extract and taxonomically related and nonrelated...

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Published in:Journal of allergy and clinical immunology 2003-05, Vol.111 (5), p.1132-1133
Main Authors: Barderas, Rodrigo, Villaba, Mayte, Batanero, Eva, Pascual, Cristina Y., Rodríguez, Rosalía
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergies
Chenopodiaceae - immunology
Contractile Proteins
Humans
Hypersensitivity - etiology
Immunoglobulin E - blood
Membranes
Microfilament Proteins - immunology
Plant Proteins - immunology
Pollen
Pollen - immunology
Profilins
Proteins
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Summary:Sensitization to Chenopodiaceae is highly concomitant with other, more ubiquitous pollinosis; thus, patients allergic to chenopod are frequently polysensitized. [...]several studies have shown a high degree of cross-reactivity between chenopod pollen extract and taxonomically related and nonrelated pollens.2Lombardero et al3and Würtzen et al4identified, respectively, notably prevalent allergenic bands of 14 and 15 kd in molecular mass in chenopod pollen, which agree with preliminary data of our group as determined by immunoblotting analyses with individual sera. Recently, a major allergen, Che a 1, has been isolated from chenopod pollen and characterized.5Although Che a 1 belongs to a wide family of pollen proteins, it shows a very limited cross-reactivity with homologous allergens such as Ole e 1 and Lol p 11--allergens from olive and ryegrass, respectively--inasmuch as they display low conserved amino acid sequences.
ISSN:0091-6749
1097-6825
DOI:10.1067/mai.2003.1445