Vecuronium: an anthropometric comparison

Summary This study set out to determine if there was any resistance to vecuronium in Nepalese studied in Nepal compared with Nepalese, Chinese and European patients studied in Hong Kong. The four groups, each of 10 male and 10 female patients, were intubated 60s after administration of 0.1 mg.kg−1 v...

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Bibliographic Details
Published in:Anaesthesia 1992-09, Vol.47 (9), p.741-746
Main Authors: HOUGHTON, I. T., AUN, C. S. T., OH, T. E.
Format: Article
Language:English
Subjects:
Adult
Anesthetics. Neuromuscular blocking agents
Anthropometry
Biological and medical sciences
China - ethnology
Continental Population Groups - genetics
Drug Resistance
Female
Genetic factors
Hong Kong
Humans
Intubation, Intratracheal
Male
Medical sciences
Muscle Relaxation - drug effects
Nepal - ethnology
Neuromuscular relaxants
Neuropharmacology
Pharmacology. Drug treatments
race
Sex Characteristics
United Kingdom - ethnology
vecuronium
Vecuronium Bromide - pharmacology
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Summary:Summary This study set out to determine if there was any resistance to vecuronium in Nepalese studied in Nepal compared with Nepalese, Chinese and European patients studied in Hong Kong. The four groups, each of 10 male and 10 female patients, were intubated 60s after administration of 0.1 mg.kg−1 vecuronium. The Nepalese patients in Nepal had significantly less satisfactory intubating conditions (p = 0.002). Similarly, male patients had significantly less satisfactory conditions than female patients (p = 0.004). Some anthropometric measurements were significantly different between the patients in Nepal and those in Hong Kong. There were also sex‐related anthropometric differences. It is suggested that differences in response to vecuronium could be explained by differences in distribution volume and muscle mass
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1992.tb03250.x