Changes in anti–U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome

Objective. To evaluate correlations between changes in anti–U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years. Methods. Anti–U1 RNA antibody levels were measured quantitatively, u...

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Bibliographic Details
Published in:Arthritis and rheumatism 1992-10, Vol.35 (10), p.1202-1210
Main Authors: Hoet, R. M., Koornneef, I., van Venrooij, W. J., de Rooij, D. J., van de Putte, L. B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autoantibodies - metabolism
Biological and medical sciences
Epitopes - immunology
Female
Follow-Up Studies
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Middle Aged
Mixed Connective Tissue Disease - complications
Mixed Connective Tissue Disease - immunology
Prospective Studies
Ribonucleoprotein, U1 Small Nuclear - genetics
Ribonucleoprotein, U1 Small Nuclear - immunology
RNA - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Syndrome
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Summary:Objective. To evaluate correlations between changes in anti–U1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years. Methods. Anti–U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index. Results. All 9 major disease exacerbations were associated with peaks in anti–U1 RNA antibody level. Conclusion. These results seem to indicate that measuring anti–U1 RNA antibody levels can be useful for monitoring disease activity.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780351013