Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function

Aims The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms...

Full description

Saved in:
Bibliographic Details
Published in:European heart journal 2003-05, Vol.24 (9), p.863-870
Main Authors: Gustafsson, Finn, Torp-Pedersen, Christian, Brendorp, Bente, Seibæk, Marie, Burchardt, Hans, Køber, Lars
Format: Article
Language:English
Subjects:
Aged
Cohort Studies
Confidence Intervals
Diastolic dysfunction
Ejection fraction
Female
Heart Failure - mortality
Heart Failure - therapy
Hospital Mortality
Hospitalization
Humans
Male
Mortality
Myocardial infarction
Prognosis
Survival Analysis
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - mortality
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis. Methods and results Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993–1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5–8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56–0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%). Conclusion In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.
ISSN:0195-668X
1522-9645
DOI:10.1016/S0195-668X(02)00845-X