In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC 50 values less than 10 μg/ml. Each medicinal p...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2003-06, Vol.86 (2), p.249-252
Main Authors: Tran, Quan Le, Tezuka, Yasuhiro, Ueda, Jun-ya, Nguyen, Nhan Trung, Maruyama, Yukiko, Begum, Khurshida, Kim, Hye-Sook, Wataya, Yusuke, Tran, Qui Kim, Kadota, Shigetoshi
Format: Article
Language:English
Subjects:
Animals
Antimalaria
Antimalarials - isolation & purification
Antimalarials - pharmacology
Antiplasmodial
Biological and medical sciences
FCR-3
General pharmacology
Medical sciences
Medicine, Traditional
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - therapeutic use
Plants, Medicinal
Plasmodium falciparum
Plasmodium falciparum - drug effects
Vietnam
Vietnamese medicinal plants
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Summary:Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC 50 values less than 10 μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC 50 value of 0.5 μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(03)00045-X