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Induction of autoimmune valvulitis in Lewis rats following immunization with peptides from the conserved region of group A streptococcal M protein
Rheumatic heart disease (RHD) is considered to be an autoimmune disorder mediated by group A streptococcal (GAS) M protein-specific T cells and antibodies that cross-react with cardiac antigens and epitopes of the GAS M protein. In this study, Lewis rats were immunized with a pool of overlapping pep...
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| Published in: | Journal of autoimmunity 2003-05, Vol.20 (3), p.211-217 |
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| container_end_page | 217 |
| container_issue | 3 |
| container_start_page | 211 |
| container_title | Journal of autoimmunity |
| container_volume | 20 |
| creator | Lymbury, Robyn S. Olive, Colleen Powell, Kellie A. Good, Michael F. Hirst, Robert G. LaBrooy, Justin T. Ketheesan, Natkunam |
| description | Rheumatic heart disease (RHD) is considered to be an autoimmune disorder mediated by group A streptococcal (GAS) M protein-specific T cells and antibodies that cross-react with cardiac antigens and epitopes of the GAS M protein. In this study, Lewis rats were immunized with a pool of overlapping peptides spanning the conserved region of the GAS M protein in Complete Freund's Adjuvant, followed by immunization with
Bordetella pertussis. Controls received adjuvants alone. Spleen-derived lymphocytes from rats immunized with the conserved region peptides proliferated in response to the immunogen and to cardiac myosin. Moreover, histological examination of cardiac tissue from rats immunized with conserved region peptides revealed the presence of inflammatory lesions in both the myocardium and valve tissue indicating a role for GAS M protein-specific autoreactive T cells in the development of cardiac lesions. This study may support the use of the rat model of autoimmune valvulitis to investigate the immunopathogenesis of RHD and possible preventive strategies. |
| doi_str_mv | 10.1016/S0896-8411(03)00026-X |
| format | article |
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Bordetella pertussis. Controls received adjuvants alone. Spleen-derived lymphocytes from rats immunized with the conserved region peptides proliferated in response to the immunogen and to cardiac myosin. Moreover, histological examination of cardiac tissue from rats immunized with conserved region peptides revealed the presence of inflammatory lesions in both the myocardium and valve tissue indicating a role for GAS M protein-specific autoreactive T cells in the development of cardiac lesions. This study may support the use of the rat model of autoimmune valvulitis to investigate the immunopathogenesis of RHD and possible preventive strategies.</description><identifier>ISSN: 0896-8411</identifier><identifier>EISSN: 1095-9157</identifier><identifier>DOI: 10.1016/S0896-8411(03)00026-X</identifier><identifier>PMID: 12753806</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Antigens, Bacterial - genetics ; Autoimmune Diseases - etiology ; Autoimmune Diseases - immunology ; Autoimmune Diseases - pathology ; Autoimmune valvulitis ; Bacterial Outer Membrane Proteins - genetics ; Bacterial Outer Membrane Proteins - immunology ; Biological and medical sciences ; Carrier Proteins - genetics ; Carrier Proteins - immunology ; Conserved Sequence ; Female ; General aspects ; Group A streptococcus ; Heart Valve Diseases - etiology ; Heart Valve Diseases - immunology ; Heart Valve Diseases - pathology ; Humans ; Immunization ; Immunopathology ; Lewis rat ; Lymphocyte Activation ; M protein ; Medical sciences ; Molecular Sequence Data ; Peptide Fragments - genetics ; Peptide Fragments - immunology ; Rats ; Rats, Inbred Lew ; Rheumatic heart disease ; Rheumatic Heart Disease - etiology ; Rheumatic Heart Disease - immunology ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - immunology ; Streptococcus pyogenes - pathogenicity ; T-Lymphocytes - immunology</subject><ispartof>Journal of autoimmunity, 2003-05, Vol.20 (3), p.211-217</ispartof><rights>2003 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-7f5622fb20aed56279de3e599f2bf8a4f7afdf2a902339ae5a208b38090ad1d13</citedby><cites>FETCH-LOGICAL-c422t-7f5622fb20aed56279de3e599f2bf8a4f7afdf2a902339ae5a208b38090ad1d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14735558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12753806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lymbury, Robyn S.</creatorcontrib><creatorcontrib>Olive, Colleen</creatorcontrib><creatorcontrib>Powell, Kellie A.</creatorcontrib><creatorcontrib>Good, Michael F.</creatorcontrib><creatorcontrib>Hirst, Robert G.</creatorcontrib><creatorcontrib>LaBrooy, Justin T.</creatorcontrib><creatorcontrib>Ketheesan, Natkunam</creatorcontrib><title>Induction of autoimmune valvulitis in Lewis rats following immunization with peptides from the conserved region of group A streptococcal M protein</title><title>Journal of autoimmunity</title><addtitle>J Autoimmun</addtitle><description>Rheumatic heart disease (RHD) is considered to be an autoimmune disorder mediated by group A streptococcal (GAS) M protein-specific T cells and antibodies that cross-react with cardiac antigens and epitopes of the GAS M protein. In this study, Lewis rats were immunized with a pool of overlapping peptides spanning the conserved region of the GAS M protein in Complete Freund's Adjuvant, followed by immunization with
Bordetella pertussis. Controls received adjuvants alone. Spleen-derived lymphocytes from rats immunized with the conserved region peptides proliferated in response to the immunogen and to cardiac myosin. Moreover, histological examination of cardiac tissue from rats immunized with conserved region peptides revealed the presence of inflammatory lesions in both the myocardium and valve tissue indicating a role for GAS M protein-specific autoreactive T cells in the development of cardiac lesions. This study may support the use of the rat model of autoimmune valvulitis to investigate the immunopathogenesis of RHD and possible preventive strategies.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens, Bacterial - genetics</subject><subject>Autoimmune Diseases - etiology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - pathology</subject><subject>Autoimmune valvulitis</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - immunology</subject><subject>Conserved Sequence</subject><subject>Female</subject><subject>General aspects</subject><subject>Group A streptococcus</subject><subject>Heart Valve Diseases - etiology</subject><subject>Heart Valve Diseases - immunology</subject><subject>Heart Valve Diseases - pathology</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunopathology</subject><subject>Lewis rat</subject><subject>Lymphocyte Activation</subject><subject>M protein</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Peptide Fragments - genetics</subject><subject>Peptide Fragments - immunology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Rheumatic heart disease</subject><subject>Rheumatic Heart Disease - etiology</subject><subject>Rheumatic Heart Disease - immunology</subject><subject>Streptococcus pyogenes - genetics</subject><subject>Streptococcus pyogenes - immunology</subject><subject>Streptococcus pyogenes - pathogenicity</subject><subject>T-Lymphocytes - immunology</subject><issn>0896-8411</issn><issn>1095-9157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkcuOFCEUhonROO3oI2jYaHRRyqUpqlZmMvEySRsXajI7QsOhB1MFJVDd0cfwiWW6K85yVpzF9_PD-RB6TslbSmj77hvp-rbp1pS-JvwNIYS1zfUDtKKkF01PhXyIVv-RM_Qk55-EUCqEeIzOKJOCd6Rdob9Xwc6m-BhwdFjPJfpxnAPgvR728-CLz9gHvIFDHZIuGbs4DPHgww4fSf9HH9MHX27wBFPxFiqU4ojLDWATQ4a0B4sT7JaWXYrzhC9wLqny0URj9IC_4CnFAj48RY-cHjI8W85z9OPjh--Xn5vN109XlxebxqwZK410omXMbRnRYOsoewscRN87tnWdXjupnXVM94Rx3msQmpFuW3_dE22ppfwcvTrdW3t_zZCLGn02MAw6QJyzkpy1nJD2XpB2suOSygqKE2hSzDmBU1Pyo06_FSXq1po6WlO3ShTh6mhNXdfci6Vg3o5g71KLpgq8XACd665c0sH4fMetJa9iu8q9P3FQ97b3kFQ2HoIB6xOYomz09zzlH5lgt_c</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Lymbury, Robyn S.</creator><creator>Olive, Colleen</creator><creator>Powell, Kellie A.</creator><creator>Good, Michael F.</creator><creator>Hirst, Robert G.</creator><creator>LaBrooy, Justin T.</creator><creator>Ketheesan, Natkunam</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030501</creationdate><title>Induction of autoimmune valvulitis in Lewis rats following immunization with peptides from the conserved region of group A streptococcal M protein</title><author>Lymbury, Robyn S. ; Olive, Colleen ; Powell, Kellie A. ; Good, Michael F. ; Hirst, Robert G. ; LaBrooy, Justin T. ; Ketheesan, Natkunam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-7f5622fb20aed56279de3e599f2bf8a4f7afdf2a902339ae5a208b38090ad1d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens, Bacterial - genetics</topic><topic>Autoimmune Diseases - etiology</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Autoimmune valvulitis</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Bacterial Outer Membrane Proteins - immunology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - immunology</topic><topic>Conserved Sequence</topic><topic>Female</topic><topic>General aspects</topic><topic>Group A streptococcus</topic><topic>Heart Valve Diseases - etiology</topic><topic>Heart Valve Diseases - immunology</topic><topic>Heart Valve Diseases - pathology</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunopathology</topic><topic>Lewis rat</topic><topic>Lymphocyte Activation</topic><topic>M protein</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Peptide Fragments - genetics</topic><topic>Peptide Fragments - immunology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Rheumatic heart disease</topic><topic>Rheumatic Heart Disease - etiology</topic><topic>Rheumatic Heart Disease - immunology</topic><topic>Streptococcus pyogenes - genetics</topic><topic>Streptococcus pyogenes - immunology</topic><topic>Streptococcus pyogenes - pathogenicity</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lymbury, Robyn S.</creatorcontrib><creatorcontrib>Olive, Colleen</creatorcontrib><creatorcontrib>Powell, Kellie A.</creatorcontrib><creatorcontrib>Good, Michael F.</creatorcontrib><creatorcontrib>Hirst, Robert G.</creatorcontrib><creatorcontrib>LaBrooy, Justin T.</creatorcontrib><creatorcontrib>Ketheesan, Natkunam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of autoimmunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lymbury, Robyn S.</au><au>Olive, Colleen</au><au>Powell, Kellie A.</au><au>Good, Michael F.</au><au>Hirst, Robert G.</au><au>LaBrooy, Justin T.</au><au>Ketheesan, Natkunam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of autoimmune valvulitis in Lewis rats following immunization with peptides from the conserved region of group A streptococcal M protein</atitle><jtitle>Journal of autoimmunity</jtitle><addtitle>J Autoimmun</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>20</volume><issue>3</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>0896-8411</issn><eissn>1095-9157</eissn><abstract>Rheumatic heart disease (RHD) is considered to be an autoimmune disorder mediated by group A streptococcal (GAS) M protein-specific T cells and antibodies that cross-react with cardiac antigens and epitopes of the GAS M protein. In this study, Lewis rats were immunized with a pool of overlapping peptides spanning the conserved region of the GAS M protein in Complete Freund's Adjuvant, followed by immunization with
Bordetella pertussis. Controls received adjuvants alone. Spleen-derived lymphocytes from rats immunized with the conserved region peptides proliferated in response to the immunogen and to cardiac myosin. Moreover, histological examination of cardiac tissue from rats immunized with conserved region peptides revealed the presence of inflammatory lesions in both the myocardium and valve tissue indicating a role for GAS M protein-specific autoreactive T cells in the development of cardiac lesions. This study may support the use of the rat model of autoimmune valvulitis to investigate the immunopathogenesis of RHD and possible preventive strategies.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>12753806</pmid><doi>10.1016/S0896-8411(03)00026-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of autoimmunity, 2003-05, Vol.20 (3), p.211-217 |
| issn | 0896-8411 1095-9157 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Amino Acid Sequence Animals Antigens, Bacterial - genetics Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune valvulitis Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - immunology Conserved Sequence Female General aspects Group A streptococcus Heart Valve Diseases - etiology Heart Valve Diseases - immunology Heart Valve Diseases - pathology Humans Immunization Immunopathology Lewis rat Lymphocyte Activation M protein Medical sciences Molecular Sequence Data Peptide Fragments - genetics Peptide Fragments - immunology Rats Rats, Inbred Lew Rheumatic heart disease Rheumatic Heart Disease - etiology Rheumatic Heart Disease - immunology Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology Streptococcus pyogenes - pathogenicity T-Lymphocytes - immunology |
| title | Induction of autoimmune valvulitis in Lewis rats following immunization with peptides from the conserved region of group A streptococcal M protein |
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