Patterns of recurrence after sentinel lymph node biopsy for breast cancer

Sentinel lymph node biopsy (SLNB) is gaining acceptance as an alternative to axillary lymph node dissection. The purpose of this study was to determine the frequency and pattern of disease recurrence after SLNB. Two-hundred twenty-two consecutive patients undergoing SLNB from April 6, 1998, to Octob...

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Bibliographic Details
Published in:Annals of surgical oncology 2003-05, Vol.10 (4), p.376-380
Main Authors: Badgwell, Brian D, Povoski, Stephen P, Abdessalam, Shahab F, Young, Donn C, Farrar, William B, Walker, Michael J, Yee, Lisa D, Zervos, Emmanuel E, Carson, 3rd, William E, Burak, Jr, William E
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - pathology
Female
Humans
Middle Aged
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Sentinel Lymph Node Biopsy
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Summary:Sentinel lymph node biopsy (SLNB) is gaining acceptance as an alternative to axillary lymph node dissection. The purpose of this study was to determine the frequency and pattern of disease recurrence after SLNB. Two-hundred twenty-two consecutive patients undergoing SLNB from April 6, 1998, to October 27, 1999, and who were >or=24 months out from their procedure were identified from a prospectively maintained database. Retrospective chart review and data analysis were performed to identify variables predictive of recurrence. The median patient follow-up was 32 months (range, 24-43 months). A total of 159 patients (72%) were sentinel lymph node (SLN) negative and had no further axillary treatment. Five of these patients (3.1%) developed a recurrence (one local and four distant), with no isolated regional (axillary) recurrences. Sixty-three patients (28%) were SLN positive and underwent a subsequent axillary lymph node dissection. Six of these patients (9.5%) developed a recurrence (three local, one regional, and two distant). Pathologic tumor size (P
ISSN:1068-9265
1534-4681
DOI:10.1245/aso.2003.07.026